Conventional / global / constitutive KO
●2 Models Available
Axin1 Conditional Knockout, Knockout mouse models
Browse 2 Axin1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Axin1 conditional knockout mouse, Axin1 knockout mouse. Contact us for availability and fast turnaround.
Why model Axin1
Axin1, the mouse ortholog of human AXIN1, encodes the concentration limiting scaffold of the beta-catenin destruction complex, using an N-terminal RGS domain to dock APC, a central segment to bind GSK3 beta and CK1 alpha, and a C-terminal DIX domain to polymerize and to engage Dishevelled DIX domains at activated LRP6 signalosomes. Its abundance is set by tankyrase mediated PARsylation and RNF146 dependent degradation, which is exactly why tankyrase inhibitors raise AXIN1 levels and suppress Wnt output. Loss of function AXIN1 mutations occur in hepatocellular carcinoma and hepatoblastoma, producing ligand-independent signaling equivalent to APC truncation. Germline null causes embryonic lethality with axis duplication in the classic Fused mutant, so hepatocyte or intestinal conditional alleles are required for tumor work. Axin2 is transcriptionally induced by Wnt and partially compensates, so double conditional stocks reveal phenotypes single deletion hides. Choose nulls for dependency and tankyrase pharmacology, and stabilization-resistant knockins to interrogate degradation control.
What Axin1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Axin1 (AXIN1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Axin1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Axin1 allele types
Knockout, conditional, knockin, humanized, and related paths for Axin1 (human AXIN1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Axin1 catalog models
2 Axin1 lines with QC documentation and technical support. Axin1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Axin1 mouse model?
We have 2 Axin1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Axin1 Mouse Model Types
A Axin1 knockout mouse has the Axin1 gene permanently inactivated, enabling loss of function studies. A Axin1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Axin1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Axin1 organized by modification type. Each URL is indexable and matches common search patterns.