Conventional / global / constitutive KO
●3 Models Available
Axin2 Knockin, Knockout mouse models
Browse 3 Axin2 mouse models including knockin, knockout variants from ingenious targeting laboratory. Available as Axin2 knockin mouse, Axin2 knockout mouse. Contact us for availability and fast turnaround.
Why model Axin2
Axin2, mouse ortholog of human AXIN2 and also called conductin, encodes a destruction complex scaffold structurally parallel to AXIN1, with RGS and DIX domains supporting APC and Dishevelled interactions, but distinguished by being a direct Wnt target gene, which makes it both a negative feedback brake and the field standard transcriptional reporter of pathway activity. Reporter knockin alleles such as Axin2-LacZ or Axin2-CreERT2 exploit that property to mark and lineage trace Wnt responsive stem cells in intestine, bone, liver and hair follicle, so allele choice here is frequently about readout rather than loss of function. Human truncating variants cause oligodontia with colorectal cancer predisposition, and null mice are viable with craniosynostosis and altered bone mass, allowing constitutive alleles. Because Axin1 is the more abundant scaffold and buffers loss, expect modest signaling change from Axin2 deletion alone. Match design to purpose: reporter or CreERT2 knockins for lineage tracing, conditional nulls layered onto Axin1 alleles for feedback dissection.
What Axin2 mouse models are available?
ingenious targeting laboratory offers 3 distinct Axin2 (AXIN2) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Axin2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Axin2 allele types
Knockout, conditional, knockin, humanized, and related paths for Axin2 (human AXIN2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Axin2 catalog models
3 Axin2 lines with QC documentation and technical support.
Looking for a Axin2 mouse model?
We have 3 Axin2 models available — including Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Axin2 Mouse Model Types
A Axin2 knockout mouse has the Axin2 gene permanently inactivated, enabling loss of function studies. Axin2 knockin models carry a precisely inserted sequence at the Axin2 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Axin2 organized by modification type. Each URL is indexable and matches common search patterns.