Conventional / global / constitutive KO
●1 Model Available
Brca2 Conditional Knockout mouse model
Browse 1 Brca2 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Brca2
Encoding the RAD51 loading factor, Brca2 is the mouse ortholog of human BRCA2 and produces a very large protein whose eight BRC repeats bind RAD51 monomers, whose DNA binding domain with the DSS1 partner engages single stranded and double stranded junctions, and whose C-terminal TR2 site stabilizes assembled filaments, together enabling strand invasion during homologous recombination and protecting stalled replication forks from MRE11 mediated degradation. Because fork protection and HR are genetically separable, allele design matters: full nulls are embryonic lethal, whereas hypomorphic truncation alleles and conditional floxed exon 11 designs permit viable tumor-prone cohorts, typically combined with Trp53 deletion and a mammary or pancreatic Cre. Biallelic hypomorphic human alleles cause Fanconi anemia subtype D1, providing a distinct developmental readout. Reversion and fork protection restoring mutations drive PARP inhibitor resistance in vivo, so knockins of specific patient variants are the right tool for resistance mechanism work rather than a generic null.
What Brca2 mouse models are available?
ingenious targeting laboratory offers 1 distinct Brca2 (BRCA2) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Brca2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Brca2 allele types
Knockout, conditional, knockin, humanized, and related paths for Brca2 (human BRCA2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Brca2 catalog models
1 Brca2 line with QC documentation and technical support. Brca2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Brca2-Flox
Conditional KnockoutKO/CKO mice, disease model mice
sperm cryopreservationCKO 200014
Looking for a Brca2 mouse model?
We have 1 Brca2 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Brca2 Mouse Model Types
A Brca2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Brca2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Brca2 organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Brca2.