Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
LIVE · SPERM
C3 Conditional Knockout, Humanized, Knockout mouse models
Browse 3 C3 mouse models including conditional knockout, humanized, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as C3 conditional knockout mouse, C3 humanized mouse, C3 knockout mouse. Request a quote within 24 hours.
Why model C3
C3, ortholog of human C3, encodes the pivotal complement component whose proteolytic activation by either the classical and lectin pathway C4b2a convertase or the alternative pathway C3bBb releases the C3a anaphylatoxin and exposes a reactive thioester in the C3b thioester-containing domain that covalently tags surfaces. Deposited C3b seeds further convertase assembly for amplification, is degraded by factor I to iC3b and C3dg for CR3, CR4, and CR2 dependent phagocytosis and B cell priming, and feeds C5 convertase formation. Loss produces pyogenic infection susceptibility, impaired immune complex clearance, and blunted antibody responses, while dysregulated turnover underlies C3 glomerulopathy and paroxysmal nocturnal hemoglobinuria pathology. No paralog compensates, making the null definitive. Humanization is the design of record for compstatin family peptides and pegcetacoplan, which bind human C3 and do not engage the mouse protein, whereas hepatocyte-conditional deletion resolves liver-derived versus local myeloid C3 contributions.
What C3 mouse models are available?
ingenious targeting laboratory offers 3 distinct C3 (C3) catalog mouse models, featuring conditional knockout, standard knockout, and humanized. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
C3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
C3 allele types
Knockout, conditional, knockin, humanized, and related paths for C3 (human C3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available C3 catalog models
3 C3 lines with QC documentation and technical support. C3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout. C3 humanized models carry the human gene sequence for translational research.
- Order
C3-Flox
CKOCKO
These mice carry loxP sites flanking exon 2-17 of C3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of C3 gene.
Sperm CryopreservedCKO 2102335 - Order
hC3
HUTarget-Humanized, Disease Model
The endogenous mouse C3 gene was replaced by human C3 gene.
LiveHU 2000079 - Order
C3-KO
KOKO
Exon 2 of C3 gene was deleted to generate C3 knockout mice.
LiveKO 191193
Selected publications from ingenious targeting laboratory
Peer reviewed work involving C3 from ingenious supported projects.
- A missense variant in SLC39A8 confers risk for Crohn’s disease by disrupting manganese homeostasis and intestinal barrier integrityNakata T, Creasey EA, Kadoki M, Lin H, Selig MK, Yao J, Lefkovith A, Daly MJ, Graham DB, Xavier RJ. (2020). Proc Natl Acad Sci U S A 117(46): 28930-28938
Looking for a C3 mouse model?
We have 3 C3 models in stock — including Conditional Knockout, Humanized, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About C3 Mouse Model Types
A C3 knockout mouse has the C3 gene permanently inactivated, enabling loss of function studies. A C3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of C3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. A C3 humanized mouse replaces the mouse C3 gene with the human ortholog for translational research and drug development.
Modifications available
Jump to catalog backed pages for C3 organized by modification type. Each URL is indexable and matches common search patterns.
C3 mouse model FAQ
What C3 Conditional Knockout mouse models are available?
When C3 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is C3 knockout embryonic lethal in mice?
It depends on background and allele design. Some C3 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live C3 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for C3?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ingenious targeting laboratory
Send the C3 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.