Conventional / global / constitutive KO
●3 Models Available
Cacna1a Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Cacna1a mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Cacna1a conditional knockout mouse, Cacna1a knockin mouse, Cacna1a knockout mouse. Request a quote within 24 hours.
Why model Cacna1a
Cacna1a is the mouse ortholog of human CACNA1A and encodes CaV2.1, the pore-forming α1A subunit of presynaptic P/Q-type calcium channels, built from four homologous repeats each contributing an S4 voltage sensor and a P-loop to the selectivity filter, with a cytoplasmic synprint motif that tethers syntaxin-1A and SNAP-25 for tight coupling of calcium entry to vesicle fusion. Three distinct human mutation classes map to different alleles: truncating loss of function causes episodic ataxia type 2, gain-of-function substitutions such as R192Q and S218L cause familial hemiplegic migraine type 1, and a C-terminal polyglutamine expansion causes spinocerebellar ataxia type 6. Constitutive nulls develop severe ataxia and dystonia and die around weaning, so cerebellar conditional deletion using Pcp2-Cre or granule cell drivers is required for adult physiology. CaV2.2 partially substitutes at some central terminals, so record paired-pulse and calcium imaging readouts rather than relying on transmitter release amplitude alone.
What Cacna1a mouse models are available?
ingenious targeting laboratory offers 3 distinct Cacna1a (CACNA1A) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cacna1a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cacna1a allele types
Knockout, conditional, knockin, humanized, and related paths for Cacna1a (human CACNA1A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cacna1a catalog models
3 Cacna1a lines with QC documentation and technical support. Cacna1a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cacna1a mouse model?
We have 3 Cacna1a models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cacna1a Mouse Model Types
A Cacna1a knockout mouse has the Cacna1a gene permanently inactivated, enabling loss of function studies. A Cacna1a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cacna1a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Cacna1a knockin models carry a precisely inserted sequence at the Cacna1a locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Cacna1a organized by modification type. Each URL is indexable and matches common search patterns.