Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
SPERM · EMBRYO
Cacna1a Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Cacna1a mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Cacna1a conditional knockout mouse, Cacna1a knockin mouse, Cacna1a knockout mouse. Contact us for availability and fast turnaround.
Why model Cacna1a
Cacna1a is the mouse ortholog of human CACNA1A and encodes CaV2.1, the pore-forming α1A subunit of presynaptic P/Q-type calcium channels, built from four homologous repeats each contributing an S4 voltage sensor and a P-loop to the selectivity filter, with a cytoplasmic synprint motif that tethers syntaxin-1A and SNAP-25 for tight coupling of calcium entry to vesicle fusion. Three distinct human mutation classes map to different alleles: truncating loss of function causes episodic ataxia type 2, gain-of-function substitutions such as R192Q and S218L cause familial hemiplegic migraine type 1, and a C-terminal polyglutamine expansion causes spinocerebellar ataxia type 6. Constitutive nulls develop severe ataxia and dystonia and die around weaning, so cerebellar conditional deletion using Pcp2-Cre or granule cell drivers is required for adult physiology. CaV2.2 partially substitutes at some central terminals, so record paired-pulse and calcium imaging readouts rather than relying on transmitter release amplitude alone.
What Cacna1a mouse models are available?
ingenious targeting laboratory offers 3 distinct Cacna1a (CACNA1A) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cacna1a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cacna1a allele types
Knockout, conditional, knockin, humanized, and related paths for Cacna1a (human CACNA1A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cacna1a catalog models
3 Cacna1a lines with QC documentation and technical support. Cacna1a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Cacna1a-Flox
CKOCKO
These mice carry loxP sites flanking exon 4 of Cacna1a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cacna1a gene.
Sperm CryopreservedCKO 2115158 - Order
Cacna1a-E1980A
KIPoint Mutation
These mice carry a E1980A mutation of Cacna1a gene.
Embryo CryopreservedKI 200279 - Order
Cacna1a-KO(2)
KOKO
The exon 3 of Cacna1a gene was deleted to generate Cacna1a knockout mouse.There have been reports of deaths caused by genetic modification. For details, click on the MGI ID in the genetic information.
Sperm CryopreservedKO 242505
Looking for a Cacna1a mouse model?
We have 3 Cacna1a models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cacna1a Mouse Model Types
A Cacna1a knockout mouse has the Cacna1a gene permanently inactivated, enabling loss of function studies. A Cacna1a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cacna1a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Cacna1a knockin models carry a precisely inserted sequence at the Cacna1a locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Cacna1a organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Cacna1a line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.