Conventional / global / constitutive KO
●2 Models Available
Cacna1d Conditional Knockout, Knockin mouse models
Browse 2 Cacna1d mouse models including conditional knockout, knockin variants from ingenious targeting laboratory. Available as Cacna1d conditional knockout mouse, Cacna1d knockin mouse. Contact us for availability and fast turnaround.
Why model Cacna1d
Cacna1d, ortholog of human CACNA1D, encodes CaV1.3, an L-type α1D channel distinguished from CaV1.2 by activation at markedly more negative potentials and by weak dihydropyridine sensitivity, properties that make it the pacemaking current in sinoatrial and adrenal chromaffin cells and the sole channel gating tonic glutamate release at cochlear inner hair cell ribbon synapses. Extensive C-terminal alternative splicing and a modulatory C-terminal domain tune calcium-dependent inactivation, and human alleles split cleanly by direction: recessive loss of function produces sinoatrial node dysfunction with deafness, whereas somatic and germline gain-of-function substitutions such as A749G cause aldosterone-producing adenomas and primary aldosteronism with seizures and neurologic disability. Constitutive nulls are viable but deaf and bradycardic, giving a tractable model, while a gain-of-function knockin isolates the aldosterone and neurodevelopmental arm. CaV1.2 compensates in several tissues, so quantify Cacna1c transcript and current before attributing residual L-type conductance.
What Cacna1d mouse models are available?
ingenious targeting laboratory offers 2 distinct Cacna1d (CACNA1D) catalog mouse models, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cacna1d model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cacna1d allele types
Knockout, conditional, knockin, humanized, and related paths for Cacna1d (human CACNA1D). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cacna1d catalog models
2 Cacna1d lines with QC documentation and technical support. Cacna1d floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cacna1d mouse model?
We have 2 Cacna1d models available — including Conditional Knockout, Knockin types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cacna1d Mouse Model Types
A Cacna1d conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cacna1d, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Cacna1d knockin models carry a precisely inserted sequence at the Cacna1d locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Cacna1d organized by modification type. Each URL is indexable and matches common search patterns.