Conventional / global / constitutive KO
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Cacna1b Conditional Knockout mouse model
Browse 1 Cacna1b mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Cacna1b
Encoding CaV2.2, the α1B pore subunit of N-type calcium channels, Cacna1b is the mouse ortholog of human CACNA1B and dominates transmitter release at nociceptive primary afferent terminals and sympathetic neurons, where it is inhibited voltage-dependently by Gβγ binding to the I-II linker downstream of opioid and GABA-B receptors and trafficked in complex with CRMP2 and collapsin response signaling. Mutually exclusive splicing of exon 37a versus 37b creates a dorsal root ganglion variant with enhanced tonic G protein modulation, and the channel is the target of the conopeptide ziconotide. Because global nulls are viable but hypoalgesic in neuropathic and inflammatory assays, the informative fork is a conditional null crossed to Advillin-Cre or Scn10a-Cre to establish afferent-specific contribution versus humanization of the outer pore and drug-binding regions for species-selective blocker pharmacology. CaV2.1 upregulates at central synapses after deletion, so include compensation controls when interpreting spinal transmission endpoints.
What Cacna1b mouse models are available?
ingenious targeting laboratory offers 1 distinct Cacna1b (CACNA1B) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cacna1b model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cacna1b allele types
Knockout, conditional, knockin, humanized, and related paths for Cacna1b (human CACNA1B). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cacna1b catalog models
1 Cacna1b line with QC documentation and technical support. Cacna1b floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Cacna1b-Flox
CKOCKO
These mice carry loxP sites flanking exon5-6 of Cacna1b gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cacna1b gene.
In DevelopmentCKO 264112
Looking for a Cacna1b mouse model?
We have 1 Cacna1b model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cacna1b Mouse Model Types
A Cacna1b conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cacna1b, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cacna1b organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Cacna1b line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.