What Cdkn2a Conditional Knockout mouse models are available?

When Cdkn2a Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Cdkn2a knockout embryonic lethal in mice?

It depends on background and allele design. Some Cdkn2a germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Cdkn2a animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Cdkn2a?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●9 Models Available

Cdkn2a Conditional Knockout, Knockin, Knockout mouse models

Browse 9 Cdkn2a mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Cdkn2a conditional knockout mouse, Cdkn2a knockin mouse, Cdkn2a knockout mouse, Cdkn2a xenograft-applicable mouse. Request a quote within 24 hours.

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Why model Cdkn2a

Cdkn2a, the mouse ortholog of human CDKN2A, is unusual because a single locus encodes two unrelated tumor suppressors from alternative reading frames: p16INK4a, an ankyrin repeat protein that allosterically inhibits CDK4 and CDK6 to keep RB hypophosphorylated, and p19ARF (human p14ARF) from an alternate first exon, which sequesters MDM2 in the nucleolus to stabilize p53. Deletion of the entire locus therefore disables the RB and p53 axes simultaneously, which is why bulk 9p21 loss is among the most common events in melanoma, glioma, pancreatic cancer and mesothelioma but is uninterpretable for mechanism. Allele design must be isoform-specific: exon 1 alpha targeted alleles remove p16 alone, exon 1 beta targeted alleles remove ARF alone, and only the combined deletion mimics the human co-deletion. Cdkn2b lies adjacent, is frequently co-deleted, and p15 partially compensates for p16 loss. Match allele to endpoint, using p16-specific alleles for CDK4/6 inhibitor sensitivity and ARF-specific alleles for p53 pathway questions.

What Cdkn2a mouse models are available?

ingenious targeting laboratory offers 9 distinct Cdkn2a (CDKN2A) catalog mouse models, featuring conditional knockout, standard knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
9 Ready Catalog Lines	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Xenograft Applicable Strains

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Xenograft Applicable Strains

Cdkn2a model types

PathAvailability

Knockout
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Conditional knockout
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Knockin
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Humanized
Request a quote
Transgenic / overexpression
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Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Cdkn2a allele types

Knockout, conditional, knockin, humanized, and related paths for Cdkn2a (human CDKN2A). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO (floxed / loxP)

Inducible conditional KO (CreER / tet)

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first (tm1a / IKMC)

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)

Tag KI (FLAG, HA, Myc, V5)

Conditional KI (e.g. Rosa26 LSL)

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Transgenic

Random integration transgenic

Safe harbor (ROSA26, HPRT, H11, Col1a1)

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre (CreER / tet)

Tamoxifen or dox inducible Cre

Dual recombinase (Cre+Dre / Cre+Flp)

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Reporter knockin (gene specific)

Standalone reporter catalog (lineage tracing, constitutive, dual reporter)

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6 (B6J / B6N)

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Ready to ship

Search 14,774 strains. Many ship from live colonies.

Browse by gene, model type, or therapeutic area. Live colonies available for many top requested knockouts, knockins, and humanized lines.

Trp53Tumor suppressor, knockout & knockin Brca1Breast cancer model, multiple alleles Rosa26Safe harbor for reporters & cassettes

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Model generation

Need a knockout, knockin, or humanized line?

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 100% germline transmission guarantee.

Conventional and conditional knockouts
Point mutation and humanized knockins
2,800+ models generated since 1998

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Available Cdkn2a catalog models

9 Cdkn2a lines with QC documentation and technical support. Cdkn2a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

Cdkn2a-Flox(p19-Flox)
Conditional Knockout
KO/CKO mice, disease model mice
sperm cryopreservationCKO 200151
Order
Cdkn2a-Flox(p16-Flox)
Conditional Knockout
KO/CKO mice
liveCKO 234392
Order
Cdkn2a-Flox(p16/p19-Flox)
Conditional Knockout
KO/CKO mice, disease model mice
liveCKO 200015
Order
Cdkn2a-2A-DreERT2(p16-2A-DreERT2)
Knockin
Cre/Dre Toolbox of Mice
liveKI 225086
Order
Cdkn2a-Luc-2A-tdTomato-2A-CreERT2(p16-Luc-2A-tdTomato-2A-CreERT2)
Knockin
Cre/Dre Toolbox of Mice, fluorescent mouse
liveKI 18039
Order
Cdkn2a-KO(p16-KO)
Knockout
KO/CKO mice
liveKO 240239
Order
Cdkn2a-KO(p19-KO)
Knockout
KO/CKO mice, disease model mice
sperm cryopreservationKO 190633
Order
Cdkn2a-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg
Xenograft-Applicable
KO/CKO mice,point mutantion mice,Cre/Dre Toolbox of Mice, random transgenic mice
embryo cryopreservationXA 234942
Order
Cdkn2a-Luc-2A-tdTomato-2A-CreERT2(p16-Luc-2A-tdTomato-2A-CreERT2)/APP/PS1(NMX)(NMX)
Xenograft-Applicable
Cre/Dre Toolbox of Mice, fluorescent mouse
embryo cryopreservationXA 251882
Order

Looking for a Cdkn2a mouse model?

We have 9 Cdkn2a models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation

About Cdkn2a Mouse Model Types

A Cdkn2a knockout mouse has the Cdkn2a gene permanently inactivated, enabling loss of function studies. A Cdkn2a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cdkn2a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Cdkn2a knockin models carry a precisely inserted sequence at the Cdkn2a locus, useful for reporter, tag, or humanization studies.

Knockout Mouse Models Conditional Knockout Mouse Models Knockin Mouse Models Mouse Model Generation Services

Modifications available

Jump to catalog backed pages for Cdkn2a organized by modification type. Each URL is indexable and matches common search patterns.

Cdkn2a Conditional Knockout Cdkn2a Knockin Cdkn2a Knockout Cdkn2a Xenograft-Applicable Cdkn2a cDNA Knockin Cdkn2a Epitope Tag Knockin Cdkn2a Humanized Cdkn2a Inducible Knockout Cdkn2a Reporter

Related Gene Targets

Cdk1 Cdk12 Cdk13 Cdk19 Cdk2 Cdk4 Cdk5 Cdk5r1 Cdk5rap2 Cdk6