Conventional / global / constitutive KO
●8 Models Available
READY TO SHIP!
LIVE · SPERM · EMBRYO
Cdkn2a Conditional Knockout, Knockin, Knockout mouse models
Browse 8 Cdkn2a mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Cdkn2a conditional knockout mouse, Cdkn2a knockin mouse, Cdkn2a knockout mouse, Cdkn2a xenograft-applicable mouse. Request a quote within 24 hours.
Why model Cdkn2a
Cdkn2a, the mouse ortholog of human CDKN2A, is unusual because a single locus encodes two unrelated tumor suppressors from alternative reading frames: p16INK4a, an ankyrin repeat protein that allosterically inhibits CDK4 and CDK6 to keep RB hypophosphorylated, and p19ARF (human p14ARF) from an alternate first exon, which sequesters MDM2 in the nucleolus to stabilize p53. Deletion of the entire locus therefore disables the RB and p53 axes simultaneously, which is why bulk 9p21 loss is among the most common events in melanoma, glioma, pancreatic cancer and mesothelioma but is uninterpretable for mechanism. Allele design must be isoform-specific: exon 1 alpha targeted alleles remove p16 alone, exon 1 beta targeted alleles remove ARF alone, and only the combined deletion mimics the human co-deletion. Cdkn2b lies adjacent, is frequently co-deleted, and p15 partially compensates for p16 loss. Match allele to endpoint, using p16-specific alleles for CDK4/6 inhibitor sensitivity and ARF-specific alleles for p53 pathway questions.
What Cdkn2a mouse models are available?
ingenious targeting laboratory offers 8 distinct Cdkn2a (CDKN2A) catalog mouse models, featuring conditional knockout, standard knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 8 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Cdkn2a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cdkn2a allele types
Knockout, conditional, knockin, humanized, and related paths for Cdkn2a (human CDKN2A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cdkn2a catalog models
8 Cdkn2a lines with QC documentation and technical support. Cdkn2a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Cdkn2a-Flox(p16/p19-Flox)
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 2 of the common region of Cdkn2a-p19ARF and Cdkn2a-p16INK4a transcripts.
Sperm CryopreservedCKO 200015 - Order
Cdkn2a-Flox(p19-Flox)
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 1 of Cdkn2a-p19ARF transcript.
Sperm CryopreservedCKO 200151 - Order
Cdkn2a-Flox(p16-Flox)
CKOCKO
These strains carry loxP sites flanking exon 1 of Cdkn2a-p16INK4a transcript.
LiveCKO 234392 - Order
Cdkn2a-2A-DreERT2(p16-2A-DreERT2)
KICre/Dre Toolbox
2A-DreERT2 expression cassette was knocked into the stop codon of the Cdkn2a gene p16INK4a transcript.
LiveKI 225086 - Order
Cdkn2a-Luc-2A-tdTomato-2A-CreERT2(p16-Luc-2A-tdTomato-2A-CreERT2)
KICre/Dre Toolbox, Fluorescent Model
A Luc-2A-tdTomato-2A-CreERT2-WPRE-pA cassette was fused in-frame with exon2 of p16INK4a transcript such that the exogenous proteins would be translated followed by the first 62aa of Cdkn2a.
LiveKI 18039 - Order
Cdkn2a-KO(p19-KO)
KOKO, Disease Model
Cdkn2a(p19) gene knockout mouse model was established by knockout exon1 of Cdkn2a-p19ARF transcript (Cdkn2a-202 transcript).
Sperm CryopreservedKO 190633 - Order
Cdkn2a-KO(p16-KO)
KOKO
Cdkn2a(p16) gene knockout mouse model was established by knockout exon1 of Cdkn2a-p16INK4a transcript (Cdkn2a-201 transcript).
Sperm CryopreservedKO 240239 - Order
Cdkn2a-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg
XAKO, Point Mutation, Cre/Dre Toolbox, Random Transgenic, Disease Model
The Cdkn2a-Flox(p16/p19-Flox) was crossed with Kras-LSL-G12D/Pdx1-Cre-Tg to generate Cdkn2a-Flox/Kras-LSL-G12D/Pdx1-Cre-Tg mice.
Embryo CryopreservedXA 234942
Looking for a Cdkn2a mouse model?
We have 8 Cdkn2a models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model8
Models Available
4
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cdkn2a Mouse Model Types
A Cdkn2a knockout mouse has the Cdkn2a gene permanently inactivated, enabling loss of function studies. A Cdkn2a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cdkn2a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Cdkn2a knockin models carry a precisely inserted sequence at the Cdkn2a locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Cdkn2a organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Cdkn2a line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.