Conventional / global / constitutive KO
●2 Models Available
Coq2 Conditional Knockout, Knockout mouse models
Browse 2 Coq2 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Coq2 conditional knockout mouse, Coq2 knockout mouse. Request a quote within 24 hours.
Why model Coq2
Coq2 encodes 4-hydroxybenzoate polyprenyltransferase, the mouse ortholog of human COQ2, an inner mitochondrial membrane enzyme that performs the committed prenylation step of coenzyme Q biosynthesis by condensing 4-hydroxybenzoate with the polyisoprenoid tail supplied by PDSS1 and PDSS2, generating the lipophilic intermediate that all downstream complex Q enzymes then modify. Recessive human alleles cause primary coenzyme Q10 deficiency presenting as steroid-resistant nephrotic syndrome, infantile encephalomyopathy and retinopathy, and a disputed association with multiple system atrophy has driven interest in heterozygous carrier biology. Because complete loss removes the substrate for every subsequent step, constitutive deletion is severely compromising and conditional nulls are the practical design, with Pax8-Cre or podocin-Cre for renal phenotypes and Nes-Cre or Dat-Cre for neurologic endpoints. No paralog performs this prenylation, so compensation is not a concern, but residual dietary and supplemental coenzyme Q10 uptake confounds rescue experiments; measure tissue CoQ9 and CoQ10 species directly.
What Coq2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Coq2 (COQ2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Coq2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Coq2 allele types
Knockout, conditional, knockin, humanized, and related paths for Coq2 (human COQ2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Coq2 catalog models
2 Coq2 lines with QC documentation and technical support. Coq2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Coq2 mouse model?
We have 2 Coq2 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Coq2 Mouse Model Types
A Coq2 knockout mouse has the Coq2 gene permanently inactivated, enabling loss of function studies. A Coq2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Coq2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Coq2 organized by modification type. Each URL is indexable and matches common search patterns.