Conventional / global / constitutive KO
●1 Model Available
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Coq3 Conditional Knockout mouse model
Browse 1 Coq3 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Coq3
The O-methylation steps of coenzyme Q biosynthesis are catalyzed by the product of Coq3, ortholog of human COQ3, a S-adenosylmethionine-dependent class I methyltransferase that is peripherally associated with the matrix face of the inner mitochondrial membrane as part of the multienzyme complex Q assembly. Uniquely among the pathway enzymes it acts twice, methylating the 3-hydroxy group of an early intermediate and then the 6-hydroxy group of demethyl-demethoxyubiquinol at the penultimate step, so its loss truncates the pathway at two distinct points and produces a characteristic accumulation of unmethylated precursors useful as a biochemical readout. Human deficiency is rare relative to COQ2, COQ6 and COQ8B but follows the same recessive coenzyme Q10 deficiency spectrum. Conditional nulls with tissue-restricted Cre drivers are the appropriate design because complete pathway ablation is poorly tolerated, and because complex Q stability is cooperative, verify COQ4, COQ7 and COQ9 protein levels before ascribing phenotypes solely to lost methyltransferase activity.
What Coq3 mouse models are available?
ingenious targeting laboratory offers 1 distinct Coq3 (COQ3) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Coq3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Coq3 allele types
Knockout, conditional, knockin, humanized, and related paths for Coq3 (human COQ3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Coq3 catalog models
1 Coq3 line with QC documentation and technical support. Coq3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Coq3-Flox
CKOCKO
These mice carry loxP sites flanking exon2 of Coq3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Coq3 gene.
In DevelopmentCKO 262693
Looking for a Coq3 mouse model?
We have 1 Coq3 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Coq3 Mouse Model Types
A Coq3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Coq3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Coq3 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Coq3 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.