Conventional / global / constitutive KO
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Coq8b Conditional Knockout mouse model
Browse 1 Coq8b mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Coq8b
Podocyte biology dominates Coq8b, ortholog of human COQ8B (ADCK4), which encodes a UbiB-family atypical kinase-like ATPase paralogous to COQ8A that binds membrane lipids and supports assembly and stability of the coenzyme Q biosynthetic complex rather than catalyzing a ring modification itself. Recessive human variants are among the more common causes of steroid-resistant nephrotic syndrome presenting in adolescence with focal segmental glomerulosclerosis, and the protein interacts with COQ6 and COQ7 as well as with the podocyte-specific machinery, which explains the renal-restricted presentation despite ubiquitous pathway requirements. Because whole-body deletion compromises multiple tissues, podocin-Cre or Nphs2-Cre conditional nulls are the design that reproduces the human glomerular phenotype, whereas a patient missense knockin preserves residual activity and supports testing of coenzyme Q10 and 2,4-dihydroxybenzoate supplementation. Coq8a is expressed in overlapping tissues but does not rescue podocyte loss, so measure glomerular coenzyme Q content and proteinuria as primary endpoints.
What Coq8b mouse models are available?
ingenious targeting laboratory offers 1 distinct Coq8b (COQ8B) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Coq8b model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Coq8b allele types
Knockout, conditional, knockin, humanized, and related paths for Coq8b (human COQ8B). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Coq8b catalog models
1 Coq8b line with QC documentation and technical support. Coq8b floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Coq8b-Flox
CKOCKO
These mice carry loxP sites flanking exon1-4 of Coq8b gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Coq8b gene.
In DevelopmentCKO 262973
Looking for a Coq8b mouse model?
We have 1 Coq8b model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Coq8b Mouse Model Types
A Coq8b conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Coq8b, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Coq8b organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Coq8b line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.