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Cox6c Knockout mouse models
Cox6c is the mouse ortholog of human COX6C and encodes a small nuclear encoded transmembrane subunit of cytochrome c oxidase added during the later assembly module together with subunits 7C and 8A, completing the peripheral shell around the mitochondrially encoded catalytic core. Subunits of this class stabilize the holoenzyme and its lipid interactions rather than participating directly in electron transfer, so depletion lowers assembled complex IV and cytochrome c oxidase activity while the heme and copper centers of surviving enzyme remain functional. The design decision is therefore whether you need absolute tissue requirement, addressed by a floxed conditional null, or a structural interface question, addressed by transmembrane substitutions that retain the subunit. No isoform paralog substitutes for 6C in somatic tissues. Direct deletion with Ckmm-Cre, Alb-Cre, or Rosa26-CreER, then quantify complex IV by spectrophotometry and histochemistry, respirometry, and assembly intermediates by blue native PAGE.
Global Cox6c deletion answers broad mechanism questions quickly. If timing or site matters, conditional alleles are a natural next step after the null is characterized.
What Cox6c Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Cox6c knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Cox6c-KO | KO | KO | DEVELOPING | KO 262726 | Inquire |
| The exon1-2 of Cox6c gene was deleted to generate Cox6c knockout mouse. | |||||
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Cox6c Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Cox6c allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Cox6c Knockout mouse models are available?
When Cox6c Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Cox6c knockout embryonic lethal in mice?
It depends on background and allele design. Some Cox6c germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Cox6c animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Cox6c?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ITL
Send the Cox6c Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.