READY TO SHIP!
DEVELOPING
Cox7c Knockout mouse models
Cox7c, ortholog of human COX7C, encodes one of the smallest nuclear encoded subunits of cytochrome c oxidase, a single transmembrane helix added with subunits 6C and 8A during the final assembly module that seals the peripheral shell around the mitochondrially encoded catalytic core. Despite its size, this subunit is required for stable holoenzyme accumulation, so loss produces isolated complex IV deficiency with reduced cytochrome c oxidase activity and accumulated subassemblies, and de novo human variants have been reported in mitochondrial disease with encephalopathy. The design fork separates absolute requirement, tested by a floxed conditional null, from interface specific questions, tested by transmembrane substitutions that keep the subunit in place and better mimic patient alleles. No isoform paralog covers 7C in somatic tissues. Direct deletion with Nes-Cre, Ckmm-Cre, or inducible Rosa26-CreER, then combine COX histochemistry, spectrophotometric complex IV activity, respirometry, and blue native assembly analysis.
Cox7c null animals are straightforward to genotype and phenotype when survival is acceptable. They remain a standard background for pharmacology, biomarker, and rescue studies.
What Cox7c Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Cox7c knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Cox7c-KO | KO | KO | DEVELOPING | KO 262178 | Inquire |
| The exon1-2 of Cox7c gene was deleted to generate Cox7c knockout mouse. | |||||
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Cox7c Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Cox7c allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Cox7c Knockout mouse models are available?
When Cox7c Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Cox7c knockout embryonic lethal in mice?
It depends on background and allele design. Some Cox7c germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Cox7c animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Cox7c?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.
Breed this line with ITL
Send the Cox7c Knockout line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.