Conventional / global / constitutive KO
●2 Models Available
E2f3 Conditional Knockout, Knockout mouse models
Browse 2 E2f3 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as E2f3 conditional knockout mouse, E2f3 knockout mouse. Contact us for availability and fast turnaround.
Why model E2f3
E2f3, the mouse ortholog of human E2F3, encodes the most proliferation-critical activator E2F and produces two isoforms from alternative promoters, E2F3a induced at the G1/S boundary and E2F3b expressed constitutively, both heterodimerizing with DP proteins and both repressed by RB pocket binding until CDK mediated phosphorylation. E2F3 loss reduces expression of the core replication program more severely than loss of E2F1 or E2F2, and E2F3 amplification at 6p22 drives bladder and small cell lung carcinoma, while E2F3 is also required for the proliferative burst that follows RB inactivation, making it the principal mediator of RB pathway dependency. Null viability is strongly strain dependent, with most nulls dying perinatally on inbred backgrounds, so conditional floxed alleles and isoform-specific knockins are the safer design. Given real redundancy with E2f1 and E2f2, compound conditional stocks are needed to expose requirement. Choose isoform-specific alleles when the question is RB pathway output versus constitutive housekeeping transcription.
What E2f3 mouse models are available?
ingenious targeting laboratory offers 2 distinct E2f3 (E2F3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
E2f3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
E2f3 allele types
Knockout, conditional, knockin, humanized, and related paths for E2f3 (human E2F3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available E2f3 catalog models
2 E2f3 lines with QC documentation and technical support. E2f3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a E2f3 mouse model?
We have 2 E2f3 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About E2f3 Mouse Model Types
A E2f3 knockout mouse has the E2f3 gene permanently inactivated, enabling loss of function studies. A E2f3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of E2f3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for E2f3 organized by modification type. Each URL is indexable and matches common search patterns.