Conventional / global / constitutive KO
●2 Models Available
Eno1 Conditional Knockout, Knockout mouse models
Browse 2 Eno1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Eno1 conditional knockout mouse, Eno1 knockout mouse. Request a quote within 24 hours.
Why model Eno1
Eno1, the mouse ortholog of human ENO1, encodes alpha-enolase, the magnesium-dependent dimeric lyase that dehydrates 2-phosphoglycerate to phosphoenolpyruvate in the payoff phase of glycolysis and supplies substrate to pyruvate kinase. Beyond catalysis the locus produces MBP-1 by alternative translation, a nuclear repressor acting at the MYC P2 promoter, and surface-displayed alpha-enolase serves as a plasminogen receptor on leukocytes and tumor cells, so phenotypes may be metabolic, transcriptional or proteolytic. Rare human ENO1 loss causes hemolytic anemia, while ENO1 deletion in glioma creates collateral lethality with ENO2 dependence. Allele strategy divides sharply: a conditional null tests glycolytic dependence within a defined lineage, a catalytically dead knockin separates enzymatic from moonlighting functions, and humanization enables evaluation of enolase inhibitors with human-selective pharmacology. Because Eno2 and Eno3 substitute in neurons and muscle respectively, confine conclusions to tissues where alpha-enolase dominates, and prioritize flux measurements over transcript abundance as endpoints.
What Eno1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Eno1 (ENO1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Eno1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Eno1 allele types
Knockout, conditional, knockin, humanized, and related paths for Eno1 (human ENO1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Eno1 mouse model?
We have 2 Eno1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Eno1 Mouse Model Types
A Eno1 knockout mouse has the Eno1 gene permanently inactivated, enabling loss of function studies. A Eno1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Eno1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Eno1 organized by modification type. Each URL is indexable and matches common search patterns.