What Eno2 Conditional Knockout mouse models are available?

When Eno2 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Eno2 knockout embryonic lethal in mice?

It depends on background and allele design. Some Eno2 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Eno2 animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Eno2?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●6 Models Available

Eno2 Conditional Knockout, Knockin, Knockout mouse models

Browse 6 Eno2 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Eno2 conditional knockout mouse, Eno2 knockin mouse, Eno2 knockout mouse, Eno2 xenograft-applicable mouse. Request a quote within 24 hours.

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Why model Eno2

Neuronal glycolysis depends on Eno2, the mouse ortholog of human ENO2, which encodes gamma-enolase (neuron-specific enolase), the isoform that replaces alpha-enolase during neuronal maturation and converts 2-phosphoglycerate to phosphoenolpyruvate; its release into serum underlies the NSE biomarker used in neuroendocrine and small cell lung tumors. Gamma-enolase additionally carries a neurotrophic, plasminogen-binding activity at the neuronal surface that promotes axonal growth, a function separable from catalysis. Design decisions hinge on which activity is under test: a conditional null with Syn1-Cre or Nes-Cre probes neuronal glycolytic reserve and synaptic energetics, a catalytically dead knockin isolates the extracellular neurotrophic role, and a humanized allele supports biomarker and inhibitor work, including glioma studies that exploit ENO1-deleted, ENO2-dependent tumors. Because Eno1 persists in glia and immature neurons, interpret residual enolase activity cautiously, and align allele with endpoints such as regional lactate flux, electrophysiology, and axon regeneration after injury.

What Eno2 mouse models are available?

ingenious targeting laboratory offers 6 distinct Eno2 (ENO2) catalog mouse models, featuring conditional knockout, standard knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
6 Ready Catalog Lines	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Xenograft Applicable Strains

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Xenograft Applicable Strains

Eno2 model types

PathAvailability

Knockout
View catalog
Conditional knockout
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Knockin
View catalog
Humanized
Request a quote
Transgenic / overexpression
Request a quote

Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Eno2 allele types

Knockout, conditional, knockin, humanized, and related paths for Eno2 (human ENO2). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO (floxed / loxP)

Inducible conditional KO (CreER / tet)

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first (tm1a / IKMC)

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)

Tag KI (FLAG, HA, Myc, V5)

Conditional KI (e.g. Rosa26 LSL)

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Transgenic

Random integration transgenic

Safe harbor (ROSA26, HPRT, H11, Col1a1)

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre (CreER / tet)

Tamoxifen or dox inducible Cre

Dual recombinase (Cre+Dre / Cre+Flp)

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Reporter knockin (gene specific)

Standalone reporter catalog (lineage tracing, constitutive, dual reporter)

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6 (B6J / B6N)

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Ready to ship

Search 14,774 strains. Many ship from live colonies.

Browse by gene, model type, or therapeutic area. Live colonies available for many top requested knockouts, knockins, and humanized lines.

Trp53Tumor suppressor, knockout & knockin Brca1Breast cancer model, multiple alleles Rosa26Safe harbor for reporters & cassettes

Browse Full Catalog

Model generation

Need a knockout, knockin, or humanized line?

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 100% germline transmission guarantee.

Conventional and conditional knockouts
Point mutation and humanized knockins
2,800+ models generated since 1998

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Available Eno2 catalog models

6 Eno2 lines with QC documentation and technical support. Eno2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

Eno2-Flox
Conditional Knockout
KO/CKO mice
liveCKO 2108331
Order
Eno2-2A-Cre
Knockin
Cre/Dre Toolbox of Mice
liveKI 200012
Order
Eno2-2A-CreERT2
Knockin
Cre/Dre Toolbox of Mice
sperm cryopreservationKI 200011
Order
Eno2-2A-CreERT2/R26-CAG-LSL-hTARDBP*A315T-EGFP
Knockin
over expression mice,Cre/Dre Toolbox of Mice, fluorescent mouse, Target humanized mice, disease model mice
sperm cryopreservationKI 234637
Order
Eno2-KO
Knockout
KO/CKO mice
embryo cryopreservationKO 2105303
Order
Eno2-Flox/Alb-Cre-Tg(NMX)
Xenograft-Applicable
KO/CKO mice,Cre/Dre Toolbox of Mice, random transgenic mice
liveXA 251739
Order

Looking for a Eno2 mouse model?

We have 6 Eno2 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation

About Eno2 Mouse Model Types

A Eno2 knockout mouse has the Eno2 gene permanently inactivated, enabling loss of function studies. A Eno2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Eno2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Eno2 knockin models carry a precisely inserted sequence at the Eno2 locus, useful for reporter, tag, or humanization studies.

Knockout Mouse Models Conditional Knockout Mouse Models Knockin Mouse Models Mouse Model Generation Services

Modifications available

Jump to catalog backed pages for Eno2 organized by modification type. Each URL is indexable and matches common search patterns.

Eno2 Conditional Knockout Eno2 Knockin Eno2 Knockout Eno2 Xenograft-Applicable Eno2 cDNA Knockin Eno2 Epitope Tag Knockin Eno2 Humanized Eno2 Inducible Knockout Eno2 Overexpression / Safe Harbor Eno2 Reporter

Related Gene Targets

Eno1 Eno3 Enox1