Conventional / global / constitutive KO
●2 Models Available
Eno3 Conditional Knockout, Xenograft-Applicable mouse models
Browse 2 Eno3 mouse models including conditional knockout, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Eno3 conditional knockout mouse, Eno3 xenograft-applicable mouse. Request a quote within 24 hours.
Why model Eno3
Skeletal muscle relies on Eno3, ortholog of human ENO3, which encodes beta-enolase, the isoform that accumulates during myogenesis and carries most 2-phosphoglycerate to phosphoenolpyruvate conversion in fast glycolytic fibers, coupling glycogenolytic flux to ATP supply during burst contraction. Recessive ENO3 mutations cause glycogen storage disease type XIII, with exercise intolerance, myalgia and elevated creatine kinase but no fixed weakness, a presentation that reflects partial rather than absolute loss of glycolytic capacity. That disease logic favors knockin of patient missense alleles over a clean null, since residual activity produces the exertional, load-dependent phenotype, whereas a muscle-restricted conditional null with Ckmm-Cre or Myf5-Cre defines the ceiling of glycolytic dependence and consequent fiber-type remodeling. Eno1 persists in muscle and partially compensates, so quantify isoform ratios before attributing any phenotype to beta-enolase. Match allele to endpoint, whether treadmill and grip performance, phosphorus 31 magnetic resonance spectroscopy of phosphocreatine recovery, or single-fiber metabolic profiling.
What Eno3 mouse models are available?
ingenious targeting laboratory offers 2 distinct Eno3 (ENO3) catalog mouse models, featuring conditional knockout and xenograft applicable lines. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Eno3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Eno3 allele types
Knockout, conditional, knockin, humanized, and related paths for Eno3 (human ENO3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Eno3 catalog models
2 Eno3 lines with QC documentation and technical support. Eno3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Eno3 mouse model?
We have 2 Eno3 models in stock — including Conditional Knockout, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Eno3 Mouse Model Types
A Eno3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Eno3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Eno3 organized by modification type. Each URL is indexable and matches common search patterns.