Conventional / global / constitutive KO
●1 Model Available
READY TO SHIP!
DEVELOPING
F13b Conditional Knockout mouse model
Browse 1 F13b mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model F13b
The carrier B subunit of factor XIII is encoded by mouse F13b, ortholog of human F13B, a plasma glycoprotein composed of ten sushi domains, also called complement control protein modules, that binds the catalytic A2 dimer to form the circulating A2B2 heterotetramer. The B subunit has no transglutaminase activity of its own; its role is to stabilize A2 in plasma, extend its half-life several fold, prevent premature calcium-dependent activation, and modulate presentation of factor XIII to fibrin, dissociating once thrombin cleaves the A subunit activation peptide so catalysis can proceed. Human F13B deficiency therefore produces a secondary reduction in circulating A subunit and a milder bleeding phenotype than A subunit deficiency, an informative dissociation between availability and catalysis. No paralog performs this carrier function. Choose the null when factor XIII stability, clearance, and plasma reservoir biology is the question, hepatocyte-conditional alleles to confirm liver source, and humanization for concentrate replacement pharmacokinetics.
What F13b mouse models are available?
ingenious targeting laboratory offers 1 distinct F13b (F13B) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
F13b model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
F13b allele types
Knockout, conditional, knockin, humanized, and related paths for F13b (human F13B). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available F13b catalog models
1 F13b line with QC documentation and technical support. F13b floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
F13b-Flox
CKOCKO
These mice carry loxP sites flanking exon1 of F13b gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of F13b gene.
In DevelopmentCKO 261600
Looking for a F13b mouse model?
We have 1 F13b model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About F13b Mouse Model Types
A F13b conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of F13b, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for F13b organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the F13b line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.