Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
SPERM
Fzd1 Conditional Knockout, Knockout mouse models
Browse 2 Fzd1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Fzd1 conditional knockout mouse, Fzd1 knockout mouse. Contact us for availability and fast turnaround.
Why model Fzd1
Fzd1, the mouse ortholog of human FZD1, encodes a seven transmembrane Frizzled receptor whose extracellular cysteine rich domain binds the palmitoleate-modified thumb of Wnt ligands, and whose intracellular KTXXXW motif recruits Dishevelled to nucleate the signalosome that, together with LRP5 or LRP6, inhibits the beta-catenin destruction complex. Receptor abundance is set post-translationally by the E3 ligases RNF43 and ZNRF3, which ubiquitinate the intracellular loops for internalization and are themselves antagonized by RSPO ligands acting through LGR4, LGR5 and LGR6, the axis exploited by porcupine and anti-FZD therapeutics. FZD1 participates in canonical signaling in kidney, lung and bone and contributes to injury responses in fibrosis. Null mice are essentially normal because ten Frizzled paralogs share ligands, with Fzd2 and Fzd7 being the closest functional relatives, so single deletion is nearly uninformative and compound conditional alleles are mandatory. Use humanized CRD knockins when the goal is testing Frizzled selective antibodies whose epitopes do not cross-react with mouse receptor.
What Fzd1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Fzd1 (FZD1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fzd1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fzd1 allele types
Knockout, conditional, knockin, humanized, and related paths for Fzd1 (human FZD1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fzd1 catalog models
2 Fzd1 lines with QC documentation and technical support. Fzd1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Fzd1-Flox
CKOCKO
These mice carry loxP sites flanking exon 1 of Fzd1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Fzd1 gene.
Sperm CryopreservedCKO 231777 - Order
Fzd1-KO
KOKO
Exon 1 of Fzd1 gene was deleted to generate Fzd1 knockout mice.
Sperm CryopreservedKO 190677
Looking for a Fzd1 mouse model?
We have 2 Fzd1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fzd1 Mouse Model Types
A Fzd1 knockout mouse has the Fzd1 gene permanently inactivated, enabling loss of function studies. A Fzd1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fzd1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fzd1 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Fzd1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.