Conventional / global / constitutive KO
●2 Models Available
Fzd2 Conditional Knockout, Knockout mouse models
Browse 2 Fzd2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Fzd2 conditional knockout mouse, Fzd2 knockout mouse. Contact us for availability and fast turnaround.
Why model Fzd2
Fzd2, mouse ortholog of human FZD2, encodes a class F seven transmembrane receptor closely related to FZD1 and FZD7, binding Wnt ligands through its cysteine rich domain and coupling to both canonical beta-catenin signaling via LRP5 and LRP6 and to planar cell polarity signaling through Dishevelled, DAAM1 and RHOA with ROCK and JNK output. Heterozygous truncating variants near the C-terminal KTXXXW and PDZ binding region cause autosomal dominant Robinow syndrome and omodysplasia, and these act as dominant alleles rather than simple loss of function, which means a conventional null will not reproduce the human disease and a targeted truncation knockin is required. FZD2 is also induced during epithelial to mesenchymal transition and supports STAT3 dependent invasion in carcinoma. Single nulls are viable with cleft palate at low penetrance, but combined Fzd1 and Fzd2 deletion produces highly penetrant palatal clefting, confirming real redundancy. Match design to question, using truncation knockins for skeletal dysplasia and compound conditional alleles for developmental requirement.
What Fzd2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Fzd2 (FZD2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fzd2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fzd2 allele types
Knockout, conditional, knockin, humanized, and related paths for Fzd2 (human FZD2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Fzd2 catalog models
2 Fzd2 lines with QC documentation and technical support. Fzd2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Fzd2 mouse model?
We have 2 Fzd2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fzd2 Mouse Model Types
A Fzd2 knockout mouse has the Fzd2 gene permanently inactivated, enabling loss of function studies. A Fzd2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fzd2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fzd2 organized by modification type. Each URL is indexable and matches common search patterns.