Conventional / global / constitutive KO
●2 Models Available
Fzd7 Conditional Knockout, Knockout mouse models
Browse 2 Fzd7 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Fzd7 conditional knockout mouse, Fzd7 knockout mouse. Request a quote within 24 hours.
Why model Fzd7
Fzd7, the mouse ortholog of human FZD7, encodes a seven-pass transmembrane Frizzled receptor whose extracellular cysteine-rich domain captures Wnt lipid-modified ligands and, together with Lrp5 or Lrp6, nucleates the signalosome that recruits Dishevelled through the intracellular KTXXXW motif. Because Fzd7 is enriched in intestinal and hepatic progenitors and is upregulated in triple-negative breast and hepatocellular tumors, it is a favored target for CRD-directed antibodies and decoy receptors, which makes the allele decision consequential: a conditional null asks whether a tissue depends on Fzd7-specific Wnt reception, a CRD humanization asks whether a clinical antibody engages its epitope and blocks ligand capture in vivo, and a signaling-dead tail mutant separates canonical output from planar cell polarity roles. Given that Fzd1, Fzd2, and Fzd5 bind overlapping Wnts and buffer single-receptor loss, compound conditional designs are prudent. Pair the chosen allele with a validated lineage driver such as Villin-Cre or Alb-Cre so the readout reflects the intended compartment.
What Fzd7 mouse models are available?
ingenious targeting laboratory offers 2 distinct Fzd7 (FZD7) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Fzd7 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Fzd7 allele types
Knockout, conditional, knockin, humanized, and related paths for Fzd7 (human FZD7). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Fzd7 mouse model?
We have 2 Fzd7 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Fzd7 Mouse Model Types
A Fzd7 knockout mouse has the Fzd7 gene permanently inactivated, enabling loss of function studies. A Fzd7 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Fzd7, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Fzd7 organized by modification type. Each URL is indexable and matches common search patterns.