Conventional / global / constitutive KO
●3 Models Available
Gabra1 Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Gabra1 mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Gabra1 conditional knockout mouse, Gabra1 knockin mouse, Gabra1 knockout mouse. Contact us for availability and fast turnaround.
Why model Gabra1
Gabra1 encodes the α1 subunit of the GABA-A receptor, ortholog of human GABRA1, and is the most abundant α isoform in brain, assembling predominantly as α1β2γ2 pentamers at synapses where the benzodiazepine site is formed at the α1 and γ2 interface and requires His101 for high-affinity diazepam binding. Dominant human variants including A322D and pore-lining substitutions cause juvenile myoclonic epilepsy and developmental and epileptic encephalopathy through dominant negative assembly failure and reduced surface receptor rather than simple haploinsufficiency. The classic knockin H101R, which renders α1 diazepam-insensitive, remains the definitive demonstration that this subunit mediates the sedative and amnestic components of benzodiazepine action, and it exemplifies the point-mutation strategy for dissecting pharmacology. Constitutive nulls are viable with tremor and near-total loss of brain benzodiazepine binding, so choose a conditional null for circuit assignment, a patient knockin for encephalopathy modeling, and pair either with EEG and interneuron-specific Cre drivers.
What Gabra1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Gabra1 (GABRA1) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gabra1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gabra1 allele types
Knockout, conditional, knockin, humanized, and related paths for Gabra1 (human GABRA1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gabra1 catalog models
3 Gabra1 lines with QC documentation and technical support. Gabra1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Gabra1 mouse model?
We have 3 Gabra1 models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gabra1 Mouse Model Types
A Gabra1 knockout mouse has the Gabra1 gene permanently inactivated, enabling loss of function studies. A Gabra1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gabra1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Gabra1 knockin models carry a precisely inserted sequence at the Gabra1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Gabra1 organized by modification type. Each URL is indexable and matches common search patterns.