Conventional / global / constitutive KO
●2 Models Available
Gabra4 Conditional Knockout, Knockout mouse models
Browse 2 Gabra4 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Gabra4 conditional knockout mouse, Gabra4 knockout mouse. Contact us for availability and fast turnaround.
Why model Gabra4
Gabra4 encodes the α4 subunit, ortholog of human GABRA4, which partners preferentially with δ rather than γ2 and localizes to extrasynaptic and perisynaptic membranes of dentate granule cells, thalamus and striatum, where α4βδ receptors mediate high-affinity tonic GABA current rather than phasic inhibition. These receptors carry an arginine at the position equivalent to α1 His101, rendering them benzodiazepine-insensitive, while remaining exquisitely sensitive to neurosteroids such as allopregnanolone, to low-dose ethanol, and to the superagonist gaboxadol, which is the pharmacological signature that defines the subunit. Expression is plastic, rising sharply after stress, ethanol withdrawal and across the ovarian cycle, so phenotyping must control for hormonal state. Constitutive nulls are viable and lose gaboxadol-sensitive tonic current, so a conditional null with Pomc-Cre or a dentate driver localizes the contribution, whereas δ subunit deletion produces overlapping phenotypes; measure tonic current amplitude directly rather than inferring from behavior.
What Gabra4 mouse models are available?
ingenious targeting laboratory offers 2 distinct Gabra4 (GABRA4) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gabra4 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gabra4 allele types
Knockout, conditional, knockin, humanized, and related paths for Gabra4 (human GABRA4). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gabra4 catalog models
2 Gabra4 lines with QC documentation and technical support. Gabra4 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Gabra4 mouse model?
We have 2 Gabra4 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gabra4 Mouse Model Types
A Gabra4 knockout mouse has the Gabra4 gene permanently inactivated, enabling loss of function studies. A Gabra4 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gabra4, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Gabra4 organized by modification type. Each URL is indexable and matches common search patterns.