Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
EMBRYO · IN PRODUCTION
Gabrg2 Conditional Knockout, Knockout mouse models
Browse 2 Gabrg2 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Gabrg2 conditional knockout mouse, Gabrg2 knockout mouse. Request a quote within 24 hours.
Why model Gabrg2
Gabrg2 encodes the γ2 subunit, ortholog of human GABRG2, present in the large majority of synaptic GABA-A receptors, where it completes the α1β2γ2 pentamer, forms the complementary face of the benzodiazepine binding site with α, and is strictly required for clustering at inhibitory postsynaptic sites through gephyrin, collybistin and neuroligin-2 interactions. Human dominant variants map cleanly to mechanism: R43Q in the benzodiazepine site causes febrile seizures and childhood absence epilepsy by impairing trafficking, K289M in the extracellular M2 to M3 loop causes generalized epilepsy with febrile seizures plus by accelerating deactivation, and truncations cause Dravet-like encephalopathy through dominant negative retention. Constitutive nulls die within the first postnatal days with loss of synaptic receptor clustering, so a conditional null with Camk2a-Cre or an interneuron driver is required for adult circuit work, while patient knockins reproduce specific seizure phenotypes. No other γ isoform substitutes appreciably in forebrain synapses.
What Gabrg2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Gabrg2 (GABRG2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gabrg2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gabrg2 allele types
Knockout, conditional, knockin, humanized, and related paths for Gabrg2 (human GABRG2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gabrg2 catalog models
2 Gabrg2 lines with QC documentation and technical support. Gabrg2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Gabrg2-Flox
CKOCKO
These mice carry loxP sites flanking exon 2 of Gabrg2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gabrg2 gene.
In production — inquireCKO 262438 - Order
Gabrg2-KO
KOKO
Exon 2 of Gabrg2 gene was deleted to generate Gabrg2 knockout mice.
F0 Embryo CryopreservedKO 190577
Looking for a Gabrg2 mouse model?
We have 2 Gabrg2 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gabrg2 Mouse Model Types
A Gabrg2 knockout mouse has the Gabrg2 gene permanently inactivated, enabling loss of function studies. A Gabrg2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gabrg2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Gabrg2 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Gabrg2 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.