Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
LIVE · SPERM
Gli1 Conditional Knockout, Knockin mouse models
Browse 2 Gli1 mouse models including conditional knockout, knockin variants — in stock and ready to ship from ingenious targeting laboratory. Available as Gli1 conditional knockout mouse, Gli1 knockin mouse. Request a quote within 24 hours.
Why model Gli1
As the mouse ortholog of human GLI1, Gli1 encodes a five-finger C2H2 zinc finger transcription factor that binds the GACCACCCA consensus and functions almost purely as an activator, lacking the strong amino-terminal repressor module of Gli3; it is itself a direct Hedgehog target gene, so its expression amplifies rather than initiates the pathway downstream of Ptch1 relief of Smoothened, with Sufu restraining nuclear entry. Because homozygous Gli1 nulls are viable and largely normal, the locus is exceptionally useful as a readout and lineage tool, and Gli1-LacZ or Gli1-CreER knockins report pathway activity and mark Hedgehog-responsive stroma, perivascular, and progenitor populations. Conditional nulls test tissue-autonomous requirements, while Rosa26-based activator expression asks whether forced GLI output suffices for transformation. Gli2 supplies most activator function and readily compensates, so single-gene loss frequently looks silent; compound Gli1 and Gli2 genetics, paired with a tamoxifen-controlled driver, keeps allele class matched to the endpoint.
What Gli1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Gli1 (GLI1) catalog mouse models, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gli1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gli1 allele types
Knockout, conditional, knockin, humanized, and related paths for Gli1 (human GLI1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gli1 catalog models
2 Gli1 lines with QC documentation and technical support. Gli1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Gli1-Flox
CKOCKO
These strains carry loxP sites flanking exon 5-9 of Gli1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gli1 gene.
Sperm CryopreservedCKO 231823 - Order
Gli1-CreERT2
KICre/Dre Toolbox
A CreERT2-Wpre-polyA expression cassette was knocked into the Gli1 gene start codon site. Gli1 encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. When these Gli1-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Gli1 expressing cells; making them useful for studying axis patterning, proliferation, and cell fate specification of Hedgehog responding cells at different stages of embryogenesis.
LiveKI 200073
Looking for a Gli1 mouse model?
We have 2 Gli1 models in stock — including Conditional Knockout, Knockin types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gli1 Mouse Model Types
A Gli1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gli1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Gli1 knockin models carry a precisely inserted sequence at the Gli1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Gli1 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Gli1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.