Conventional / global / constitutive KO
●2 Models Available
Gli1 Conditional Knockout, Knockin mouse models
Browse 2 Gli1 mouse models including conditional knockout, knockin variants — in stock and ready to ship from ingenious targeting laboratory. Available as Gli1 conditional knockout mouse, Gli1 knockin mouse. Request a quote within 24 hours.
Why model Gli1
As the mouse ortholog of human GLI1, Gli1 encodes a five-finger C2H2 zinc finger transcription factor that binds the GACCACCCA consensus and functions almost purely as an activator, lacking the strong amino-terminal repressor module of Gli3; it is itself a direct Hedgehog target gene, so its expression amplifies rather than initiates the pathway downstream of Ptch1 relief of Smoothened, with Sufu restraining nuclear entry. Because homozygous Gli1 nulls are viable and largely normal, the locus is exceptionally useful as a readout and lineage tool, and Gli1-LacZ or Gli1-CreER knockins report pathway activity and mark Hedgehog-responsive stroma, perivascular, and progenitor populations. Conditional nulls test tissue-autonomous requirements, while Rosa26-based activator expression asks whether forced GLI output suffices for transformation. Gli2 supplies most activator function and readily compensates, so single-gene loss frequently looks silent; compound Gli1 and Gli2 genetics, paired with a tamoxifen-controlled driver, keeps allele class matched to the endpoint.
What Gli1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Gli1 (GLI1) catalog mouse models, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gli1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gli1 allele types
Knockout, conditional, knockin, humanized, and related paths for Gli1 (human GLI1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gli1 catalog models
2 Gli1 lines with QC documentation and technical support. Gli1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Gli1 mouse model?
We have 2 Gli1 models in stock — including Conditional Knockout, Knockin types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gli1 Mouse Model Types
A Gli1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gli1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Gli1 knockin models carry a precisely inserted sequence at the Gli1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Gli1 organized by modification type. Each URL is indexable and matches common search patterns.