Conventional / global / constitutive KO
●2 Models Available
Gli2 Conditional Knockout, Knockout mouse models
Browse 2 Gli2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Gli2 conditional knockout mouse, Gli2 knockout mouse. Contact us for availability and fast turnaround.
Why model Gli2
Gli2, the mouse ortholog of human GLI2, encodes the principal transcriptional activator of Hedgehog signaling, a zinc finger protein bearing an amino-terminal repressor domain, a Sufu-binding region, and carboxy-terminal transactivation sequences; unlike Gli3, it is only inefficiently processed into a repressor form, and its activity is set by PKA-primed GSK3 and CK1 phosphorylation, Spop-directed degradation, and Kif7-dependent trafficking within the primary cilium. Homozygous nulls die perinatally with cleft palate, skeletal and vertebral defects, and lung and foregut abnormalities, so tissue-restricted floxed alleles are the practical route for postnatal or organ-specific questions. A conditional null asks whether a lineage requires activator output, an amino-terminally truncated constitutively active knockin asks whether GLI2 output alone drives proliferation or tumor initiation, and degron-resistant variants isolate turnover from transcription. Gli1 and Gli3 partially buffer loss, arguing for compound alleles, and a well-characterized Cre with confirmed recombination efficiency matters as much as the flox itself.
What Gli2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Gli2 (GLI2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Gli2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Gli2 allele types
Knockout, conditional, knockin, humanized, and related paths for Gli2 (human GLI2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Gli2 catalog models
2 Gli2 lines with QC documentation and technical support. Gli2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Gli2 mouse model?
We have 2 Gli2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Gli2 Mouse Model Types
A Gli2 knockout mouse has the Gli2 gene permanently inactivated, enabling loss of function studies. A Gli2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Gli2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Gli2 organized by modification type. Each URL is indexable and matches common search patterns.