Conventional / global / constitutive KO
●4 Models Available
Havcr2 Conditional Knockout, Knockout mouse models
Browse 4 Havcr2 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Havcr2 conditional knockout mouse, Havcr2 knockout mouse. Request a quote within 24 hours.
Why model Havcr2
Havcr2 encodes TIM-3, the mouse ortholog of human HAVCR2, an immunoglobulin V-type domain plus mucin stalk receptor expressed on exhausted CD8 T cells, Th1 cells, NK cells, and myeloid populations, with reported ligands including galectin 9, phosphatidylserine, CEACAM1, and HMGB1. Unlike PD-1 it carries no ITIM or ITSM, and instead its cytoplasmic tyrosines Y256 and Y263 are phosphorylated to displace HLA-B associated transcript 3 and permit Fyn dependent inhibitory signaling, which is why TIM-3 behaves as a context dependent regulator rather than a simple brake. Germline loss-of-function HAVCR2 variants cause subcutaneous panniculitis-like T cell lymphoma with hemophagocytic syndrome, giving a genuine disease knockin rationale distinct from a null. Because clinical antibodies do not cross-react, humanization is the allele for pharmacology, while conditional nulls with Cd4-Cre or Lyz2-Cre separate lymphoid from myeloid contributions, and combining with Pdcd1 loss is usually required before checkpoint phenotypes become measurable.
What Havcr2 mouse models are available?
ingenious targeting laboratory offers 4 distinct Havcr2 (TIM-3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Havcr2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Havcr2 allele types
Knockout, conditional, knockin, humanized, and related paths for Havcr2 (human HAVCR2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Havcr2 catalog models
4 Havcr2 lines with QC documentation and technical support. Havcr2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Havcr2 mouse model?
We have 4 Havcr2 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Havcr2 Mouse Model Types
A Havcr2 knockout mouse has the Havcr2 gene permanently inactivated, enabling loss of function studies. A Havcr2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Havcr2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Havcr2 organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Havcr2.