Conventional / global / constitutive KO
●2 Models Available
Idh1 Conditional Knockout, Knockout mouse models
Browse 2 Idh1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Idh1 conditional knockout mouse, Idh1 knockout mouse. Contact us for availability and fast turnaround.
Why model Idh1
Cytosolic isocitrate dehydrogenase 1, encoded by Idh1 and orthologous to human IDH1, catalyzes the NADP-dependent oxidative decarboxylation of isocitrate to alpha-ketoglutarate in the cytoplasm and peroxisomes, supplying reducing equivalents for lipid synthesis and oxidative defense. Tumor alleles are heterozygous missense substitutions at arginine 132, most often R132H, which convert the enzyme into a neomorph that further reduces alpha-ketoglutarate to the oncometabolite D-2-hydroxyglutarate. Accumulated D-2HG competitively inhibits alpha-ketoglutarate dependent dioxygenases including TET2, the KDM4 and KDM6 demethylases, and prolyl hydroxylases, producing the CpG island hypermethylator phenotype and differentiation block characteristic of low grade glioma, chondrosarcoma, cholangiocarcinoma, and acute myeloid leukemia. Because the retained wild type allele is mechanistically required, the correct model is a conditional Lox-Stop-Lox R132H knockin at the endogenous locus rather than a null. Match Cre timing and lineage to the tumor type and use D-2HG suppression as the pharmacodynamic endpoint.
What Idh1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Idh1 (IDH1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Idh1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Idh1 allele types
Knockout, conditional, knockin, humanized, and related paths for Idh1 (human IDH1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Idh1 catalog models
2 Idh1 lines with QC documentation and technical support. Idh1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Idh1 mouse model?
We have 2 Idh1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Idh1 Mouse Model Types
A Idh1 knockout mouse has the Idh1 gene permanently inactivated, enabling loss of function studies. A Idh1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Idh1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Idh1 organized by modification type. Each URL is indexable and matches common search patterns.