Conventional / global / constitutive KO
●1 Model Available
Idh2 Conditional Knockout mouse model
Browse 1 Idh2 mouse model including conditional knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.
Why model Idh2
Idh2, the mouse ortholog of human IDH2, encodes the mitochondrial NADP-dependent isocitrate dehydrogenase that operates inside the matrix to generate alpha-ketoglutarate and NADPH for glutathione and thioredoxin regeneration, distinguishing it from the NAD-dependent heterotrimeric IDH3 that carries flux through the tricarboxylic acid cycle. Cancer alleles are heterozygous substitutions at arginine 140, most often R140Q in acute myeloid leukemia, and at arginine 172 in leukemia and glioma, each producing the same neomorphic reduction of alpha-ketoglutarate to D-2-hydroxyglutarate that inhibits TET2, the JmjC demethylases, and collagen prolyl hydroxylases, driving DNA and histone hypermethylation with a block in myeloid differentiation. Conditional Lox-Stop-Lox knockin of the specific residue, not deletion, reproduces this biology, and the choice between R140Q and R172K matters because they differ in enzymatic output and inhibitor sensitivity. Use an inducible hematopoietic Cre, and pair with Flt3 or Npm1 alleles when full transformation is the endpoint.
What Idh2 mouse models are available?
ingenious targeting laboratory offers 1 distinct Idh2 (IDH2) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Idh2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Idh2 allele types
Knockout, conditional, knockin, humanized, and related paths for Idh2 (human IDH2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Idh2 catalog models
1 Idh2 line with QC documentation and technical support. Idh2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Idh2-Flox
Conditional KnockoutKO/CKO mice, disease model mice
liveCKO 205094
Looking for a Idh2 mouse model?
We have 1 Idh2 model in stock — including Conditional Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Idh2 Mouse Model Types
A Idh2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Idh2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Idh2 organized by modification type. Each URL is indexable and matches common search patterns.