Conventional / global / constitutive KO
●2 Models Available
Ikbkb Conditional Knockout, Knockout mouse models
Browse 2 Ikbkb mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Ikbkb conditional knockout mouse, Ikbkb knockout mouse. Contact us for availability and fast turnaround.
Why model Ikbkb
Ikbkb, the mouse ortholog of human IKBKB, encodes IKK2, the dominant catalytic subunit of the IkB kinase complex, which also contains Chuk-encoded IKK1 and the Ikbkg scaffold; once Tak1 phosphorylates the activation loop at Ser177 and Ser181, IKK2 phosphorylates IkBalpha on Ser32 and Ser36, triggering betaTrCP-dependent ubiquitination and proteasomal destruction and freeing RelA and p50 dimers for nuclear entry. Homozygous deletion causes mid-gestation lethality from TNF-driven hepatocyte apoptosis, which can be rescued on a Tnfr1-deficient background but otherwise mandates conditional alleles, so lineage-restricted deletion with LysM-Cre, Cd19-Cre, or Villin-Cre is the practical route for inflammation and tumor studies. A constitutively active Ser177 and Ser181 to glutamate knockin asks whether canonical NF-kB output alone drives a phenotype, a kinase-dead allele distinguishes catalysis from complex assembly, and humanization supports selective inhibitor pharmacology. Chuk partially compensates, so pair compound alleles with a driver validated in the target compartment.
What Ikbkb mouse models are available?
ingenious targeting laboratory offers 2 distinct Ikbkb (IKBKB) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ikbkb model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ikbkb allele types
Knockout, conditional, knockin, humanized, and related paths for Ikbkb (human IKBKB). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ikbkb catalog models
2 Ikbkb lines with QC documentation and technical support. Ikbkb floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Ikbkb mouse model?
We have 2 Ikbkb models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ikbkb Mouse Model Types
A Ikbkb knockout mouse has the Ikbkb gene permanently inactivated, enabling loss of function studies. A Ikbkb conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ikbkb, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ikbkb organized by modification type. Each URL is indexable and matches common search patterns.