Conventional / global / constitutive KO
●3 Models Available
Ikbke Conditional Knockout, Knockout mouse models
Browse 3 Ikbke mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Ikbke conditional knockout mouse, Ikbke knockout mouse. Contact us for availability and fast turnaround.
Why model Ikbke
Ikbke encodes IKK epsilon, the mouse ortholog of human IKBKE and the noncanonical IKK family kinase most closely related to TBK1, sharing a kinase domain, ubiquitin-like domain, and scaffold dimerization region. Together with TBK1 it phosphorylates IRF3 on the C-terminal serine cluster to license interferon beta transcription, and it also phosphorylates STAT1 at Ser708 to reshape ISGF3 output and modifies NF-kB regulators including CYLD, which underlies its behavior as an amplified breast cancer oncogene able to substitute for AKT driven survival signaling. Design follows the question directly: a conditional null removes protein and scaffolding together, whereas a kinase-dead knockin distinguishes catalytic activity from complex assembly, the decisive comparison for evaluating small molecule inhibitors. Substantial redundancy with Tbk1 means single deletion blunts rather than abolishes interferon induction, and because Tbk1 nulls die in utero from TNF driven hepatocyte apoptosis, compound experiments require conditional Tbk1 alleles planned in advance.
What Ikbke mouse models are available?
ingenious targeting laboratory offers 3 distinct Ikbke (IKBKE) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ikbke model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ikbke allele types
Knockout, conditional, knockin, humanized, and related paths for Ikbke (human IKBKE). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ikbke catalog models
3 Ikbke lines with QC documentation and technical support. Ikbke floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Ikbke mouse model?
We have 3 Ikbke models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ikbke Mouse Model Types
A Ikbke knockout mouse has the Ikbke gene permanently inactivated, enabling loss of function studies. A Ikbke conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ikbke, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ikbke organized by modification type. Each URL is indexable and matches common search patterns.