Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
EMBRYO · IN PRODUCTION
Inhbb Conditional Knockout, Knockout mouse models
Browse 2 Inhbb mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Inhbb conditional knockout mouse, Inhbb knockout mouse. Request a quote within 24 hours.
Why model Inhbb
Activin B, activin AB, and inhibin B all derive from the beta B subunit encoded by Inhbb, the mouse ortholog of human INHBB, which engages ActRIIA or ActRIIB with ALK4 and, distinctively, with ALK7 to activate SMAD2 and SMAD3, a receptor preference that separates activin B pharmacology from activin A. Nulls survive but display defective eyelid closure at birth alongside reproductive, placental, and pancreatic islet abnormalities, while inhibin B serves clinically as a Sertoli cell and ovarian reserve marker. Conditional deletion is the right tool for adult liver regeneration, beta-cell, and hepatic iron questions where the perinatal ocular phenotype would otherwise confound interpretation. Subunit-swap and patient variant knockins test ligand-specific receptor usage, and humanization supports antibody and ligand trap development. Inhba shares receptors and expression domains extensively, so compound Inhba and Inhbb conditional alleles, with a driver validated in the relevant lineage, prevent misreading redundancy as dispensability.
What Inhbb mouse models are available?
ingenious targeting laboratory offers 2 distinct Inhbb (INHBB) catalog mouse models in the TGF-beta/Activin/Nodal family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Inhbb model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Inhbb allele types
Knockout, conditional, knockin, humanized, and related paths for Inhbb (human INHBB). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Inhbb catalog models
2 Inhbb lines with QC documentation and technical support. Inhbb floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Inhbb-Flox
CKOCKO
These mice carry loxP sites flanking exon 2 of Inhbb gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Inhbb gene.
In production — inquireCKO 253951 - Order
Inhbb-KO
KOKO
Exon 2 of Inhbb gene was deleted to generate Inhbb knockout mice.
Embryo CryopreservedKO 200264
Looking for a Inhbb mouse model?
We have 2 Inhbb models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Inhbb Mouse Model Types
A Inhbb knockout mouse has the Inhbb gene permanently inactivated, enabling loss of function studies. A Inhbb conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Inhbb, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Inhbb organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Inhbb line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.