Conventional / global / constitutive KO
●2 Models Available
Insr Conditional Knockout, Knockout mouse models
Browse 2 Insr mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Insr conditional knockout mouse, Insr knockout mouse. Contact us for availability and fast turnaround.
Why model Insr
Insr, the mouse ortholog of human INSR, encodes a disulfide-linked receptor tyrosine kinase assembled as an alpha-beta heterotetramer, with L1, L2, and cysteine-rich ligand-binding modules and a kinase domain whose activation loop tyrosines undergo trans-autophosphorylation on insulin binding, creating NPXY docking sites for Irs1 and Irs2 that route signals into PI3K, Akt, and Foxo1 as well as Shc-dependent Erk activation; exon 11 splicing generates IR-A and IR-B isoforms with different affinities and tissue distributions. Homozygous nulls are born grossly normal but die within days from ketoacidosis, mirroring human Donohue syndrome, so tissue-restricted deletion with Alb-Cre, Ckmm-Cre, Adipoq-Cre, or Ins1-Cre is the standard approach for dissecting organ-specific insulin action. Kinase-dead and NPXY-mutant knockins separate catalysis from scaffolding, and humanization supports analog and bispecific antibody testing. Igf1r is a close paralog that forms hybrid receptors and buffers signaling, so compound alleles are often necessary.
What Insr mouse models are available?
ingenious targeting laboratory offers 2 distinct Insr (INSR) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Insr model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Insr allele types
Knockout, conditional, knockin, humanized, and related paths for Insr (human INSR). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Insr catalog models
2 Insr lines with QC documentation and technical support. Insr floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Insr mouse model?
We have 2 Insr models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Insr Mouse Model Types
A Insr knockout mouse has the Insr gene permanently inactivated, enabling loss of function studies. A Insr conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Insr, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Insr organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Insr.