Conventional / global / constitutive KO
●2 Models Available
Irf3 Conditional Knockout, Knockout mouse models
Browse 2 Irf3 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Irf3 conditional knockout mouse, Irf3 knockout mouse. Contact us for availability and fast turnaround.
Why model Irf3
Irf3 corresponds to human IRF3 and encodes a constitutively expressed interferon regulatory factor with an N-terminal winged helix DNA binding domain and a C-terminal IRF association domain held autoinhibited until TBK1 or IKK epsilon phosphorylate the serine-rich tail at Ser386 and Ser396 downstream of STING, MAVS, or TRIF. Phosphorylation drives dimerization, nuclear accumulation, CBP and p300 recruitment, and transcription of Ifnb1 with early interferon stimulated genes, while a transcription independent arm, the RLR induced apoptotic pathway, uses BH3 like engagement of BAX to kill infected cells. Allele forks map cleanly onto these functions: conditional nulls test requirement, phosphomimetic constitutively active knockins model chronic interferon tone, and mutations separating transactivation from BAX binding isolate the apoptotic arm. Irf7 substantially overlaps in interferon induction, so compound Irf3 with Irf7 deletion is usually required before output is truly abolished, and STING gain-of-function crosses need conditional alleles to survive breeding.
What Irf3 mouse models are available?
ingenious targeting laboratory offers 2 distinct Irf3 (IRF3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Irf3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Irf3 allele types
Knockout, conditional, knockin, humanized, and related paths for Irf3 (human IRF3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Irf3 catalog models
2 Irf3 lines with QC documentation and technical support. Irf3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Irf3 mouse model?
We have 2 Irf3 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Irf3 Mouse Model Types
A Irf3 knockout mouse has the Irf3 gene permanently inactivated, enabling loss of function studies. A Irf3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Irf3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Irf3 organized by modification type. Each URL is indexable and matches common search patterns.