Conventional / global / constitutive KO
●2 Models Available
Irf5 Conditional Knockout, Knockout mouse models
Browse 2 Irf5 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Irf5 conditional knockout mouse, Irf5 knockout mouse. Contact us for availability and fast turnaround.
Why model Irf5
Irf5 is the mouse ortholog of human IRF5 and encodes an interferon regulatory factor acting mainly downstream of MyD88 coupled TLR7 and TLR9 signaling, where TRAF6 dependent ubiquitination and IKKbeta mediated phosphorylation drive nuclear translocation and transcription of interleukin 6, interleukin 12, interleukin 23, and TNF, making it a determinant of inflammatory macrophage polarization and plasma cell differentiation rather than of type I interferon amplification. Human IRF5 haplotypes are among the strongest non-HLA risk factors for systemic lupus erythematosus, giving clear rationale for both loss-of-function and expression level alleles. One technical caveat dominates this locus: several widely used Irf5 knockout lines carried a closely linked spontaneous Dock2 mutation that independently distorts lymphocyte development and migration, so new projects should use a freshly targeted conditional allele and genotype Dock2 explicitly. Pair the flox with Lyz2-Cre or Cd19-Cre to separate myeloid from B lineage contributions, and humanize when antibody or degrader pharmacology is the endpoint.
What Irf5 mouse models are available?
ingenious targeting laboratory offers 2 distinct Irf5 (IRF5) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Irf5 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Irf5 allele types
Knockout, conditional, knockin, humanized, and related paths for Irf5 (human IRF5). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Irf5 catalog models
2 Irf5 lines with QC documentation and technical support. Irf5 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Irf5 mouse model?
We have 2 Irf5 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Irf5 Mouse Model Types
A Irf5 knockout mouse has the Irf5 gene permanently inactivated, enabling loss of function studies. A Irf5 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Irf5, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Irf5 organized by modification type. Each URL is indexable and matches common search patterns.