Conventional / global / constitutive KO
●2 Models Available
Jag2 Conditional Knockout, Knockout mouse models
Browse 2 Jag2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Jag2 conditional knockout mouse, Jag2 knockout mouse. Contact us for availability and fast turnaround.
Why model Jag2
Jag2, the mouse ortholog of human JAG2, encodes a second Jagged-class Notch ligand and presents a DSL domain with EGF repeats to NOTCH1 through NOTCH3, triggering force-dependent ADAM10 and gamma-secretase processing and NICD-driven transcription with RBPJ and MAML. Its non-redundant requirements concentrate in thymic epithelium and gamma delta T cell development, the limb apical ectodermal ridge, tooth, and secondary palate, and nulls die perinatally with cleft palate, limb syndactyly, and thymic hypoplasia, while biallelic human variants cause a recessive muscular dystrophy tied to satellite cell Notch signaling. Given perinatal lethality, conditional deletion is the practical design for postnatal thymus, muscle regeneration, or skin work, patient missense knockins test whether variants impair surface presentation or receptor binding, and humanization supports antibody pharmacology. Jag1 overlaps substantially in epithelial and vascular contexts, so compound conditional alleles paired with a lineage-validated Cre driver prevent masked phenotypes.
What Jag2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Jag2 (JAG2) catalog mouse models in the Notch ligand family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Jag2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Jag2 allele types
Knockout, conditional, knockin, humanized, and related paths for Jag2 (human JAG2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Jag2 catalog models
2 Jag2 lines with QC documentation and technical support. Jag2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Jag2 mouse model?
We have 2 Jag2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Jag2 Mouse Model Types
A Jag2 knockout mouse has the Jag2 gene permanently inactivated, enabling loss of function studies. A Jag2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Jag2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Jag2 organized by modification type. Each URL is indexable and matches common search patterns.