Conventional / global / constitutive KO
●2 Models Available
Kmt2a Conditional Knockout, Knockout mouse models
Browse 2 Kmt2a mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Kmt2a conditional knockout mouse, Kmt2a knockout mouse. Contact us for availability and fast turnaround.
Why model Kmt2a
Trithorax-family biology begins with Kmt2a, the mouse ortholog of human KMT2A (MLL1), whose C-terminal SET domain deposits H3K4 methylation at Hox loci after taspase1 cleavage and reassembly of the N-terminal and C-terminal fragments, with catalysis requiring the WRAD module (WDR5, RBBP5, ASH2L, DPY30) and locus targeting through menin, LEDGF, and CXXC-mediated CpG binding. Leukemogenesis proceeds not by point mutation but by 11q23 translocation, generating in-frame fusions such as MLL-AF9 or MLL-AF4 that retain the CXXC domain, recruit DOT1L and the super elongation complex, and enforce HOXA9 and MEIS1 expression. Allele design splits accordingly: conditional nulls test methyltransferase dependence and hematopoietic stem cell output, SET-dead knockins isolate catalysis, and inducible fusion knockins at the endogenous locus produce latency-appropriate leukemia. Germline nulls are embryonic lethal near midgestation while heterozygotes show skeletal and hematopoietic haploinsufficiency, and the paralog Kmt2b partially overlaps, so compound conditionals with a validated hematopoietic Cre are advisable.
What Kmt2a mouse models are available?
ingenious targeting laboratory offers 2 distinct Kmt2a (MLL) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Kmt2a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Kmt2a allele types
Knockout, conditional, knockin, humanized, and related paths for Kmt2a (human KMT2A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Kmt2a catalog models
2 Kmt2a lines with QC documentation and technical support. Kmt2a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Kmt2a mouse model?
We have 2 Kmt2a models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Kmt2a Mouse Model Types
A Kmt2a knockout mouse has the Kmt2a gene permanently inactivated, enabling loss of function studies. A Kmt2a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kmt2a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Kmt2a organized by modification type. Each URL is indexable and matches common search patterns.