Conventional / global / constitutive KO
●2 Models Available
Kmt2c Conditional Knockout, Knockout mouse models
Browse 2 Kmt2c mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Kmt2c conditional knockout mouse, Kmt2c knockout mouse. Contact us for availability and fast turnaround.
Why model Kmt2c
Enhancer methylation studies require Kmt2c, the mouse ortholog of human KMT2C (MLL3), a SET domain monomethyltransferase that, with its close paralog Kmt2d, forms COMPASS-like complexes containing NCOA6, PTIP, PA1, and the demethylase UTX to deposit H3K4me1 and license distal regulatory elements for p53, estrogen receptor, and lineage transcription factor output. Truncating and inactivating missense mutations accumulate across breast carcinoma, bladder cancer, medulloblastoma, and myeloid neoplasms, frequently as 7q deletions in the hematopoietic setting, so the disease-relevant allele is loss of function, often at haploinsufficient dosage, rather than hyperactivity. Model design consequently forks between conditional nulls that expose enhancer decommissioning and differentiation defects, SET-dead knockins that separate catalytic from scaffolding contributions, and humanized alleles for variant classification. Redundancy is real and quantitative, since Kmt2d covers overlapping enhancer sets, so compound conditional genetics should be planned upfront, and endpoint choice, whether tumor latency with a cooperating driver or chromatin profiling, dictates the appropriate Cre.
What Kmt2c mouse models are available?
ingenious targeting laboratory offers 2 distinct Kmt2c (KMT2C) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Kmt2c model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Kmt2c allele types
Knockout, conditional, knockin, humanized, and related paths for Kmt2c (human KMT2C). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Kmt2c catalog models
2 Kmt2c lines with QC documentation and technical support. Kmt2c floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Kmt2c mouse model?
We have 2 Kmt2c models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Kmt2c Mouse Model Types
A Kmt2c knockout mouse has the Kmt2c gene permanently inactivated, enabling loss of function studies. A Kmt2c conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kmt2c, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Kmt2c organized by modification type. Each URL is indexable and matches common search patterns.