Conventional / global / constitutive KO
●1 Model Available
Kmt2d Conditional Knockout mouse model
Browse 1 Kmt2d mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Kmt2d
Among enhancer regulators, Kmt2d is the mouse ortholog of human KMT2D (MLL2 or MLL4) and the dominant H3K4 monomethyltransferase of the COMPASS-like complex, working through NCOA6, PTIP, PA1, RBBP5, ASH2L, and UTX to prime enhancers that drive B cell, cardiac, and neural differentiation programs. Heterozygous truncating variants cause Kabuki syndrome, while somatic nonsense and frameshift mutations dominate follicular lymphoma, diffuse large B cell lymphoma, bladder carcinoma, and lung squamous cancer, implicating enhancer collapse and impaired germinal center exit rather than gain of function. Because germline nulls die in midgestation with cardiac and neural tube defects, conditional nulls remain the practical route for lineage-restricted enhancer studies, whereas SET-dead knockins separate catalysis from scaffolding and humanized alleles support classification of clinical missense variants. The paralog Kmt2c shares substrate and complex membership, so masked phenotypes are a genuine risk; align allele class with endpoint and use germinal center drivers such as Cgamma1-cre for lymphomagenesis.
What Kmt2d mouse models are available?
ingenious targeting laboratory offers 1 distinct Kmt2d (KMT2D) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Kmt2d model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Kmt2d allele types
Knockout, conditional, knockin, humanized, and related paths for Kmt2d (human KMT2D). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Kmt2d catalog models
1 Kmt2d line with QC documentation and technical support. Kmt2d floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Kmt2d-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 215037
Looking for a Kmt2d mouse model?
We have 1 Kmt2d model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Kmt2d Mouse Model Types
A Kmt2d conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Kmt2d, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Kmt2d organized by modification type. Each URL is indexable and matches common search patterns.