Conventional / global / constitutive KO
●2 Models Available
Mapk14 Conditional Knockout, Knockout mouse models
Browse 2 Mapk14 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Mapk14 conditional knockout mouse, Mapk14 knockout mouse. Contact us for availability and fast turnaround.
Why model Mapk14
Mapk14, the mouse ortholog of human MAPK14, encodes p38alpha, a stress-activated MAP kinase phosphorylated on the Thr and Tyr residues of its TGY motif by Map2k3 and Map2k6 downstream of Tak1, Ask1, and Map3k7 in response to inflammatory cytokines, osmotic stress, and DNA damage; its substrates include Mapkapk2, Mknk1, Atf2, Mef2c, and Tp53, and it governs Tnf and Il1b mRNA stability through the MK2 and tristetraprolin axis. A Thr106 gatekeeper residue defines the ATP pocket exploited by pyridinylimidazole inhibitors, which is why a Thr106Met knockin creating a drug-resistant kinase remains the most rigorous in vivo test of on-target inhibitor action. Homozygous nulls die at mid-gestation from placental defects that tetraploid complementation rescues, so conditional deletion is standard for immune and cardiac studies. Mapk11, Mapk12, and Mapk13 encode the other p38 isoforms with partially shared substrates, so compound alleles and a validated lineage driver protect against masked phenotypes.
What Mapk14 mouse models are available?
ingenious targeting laboratory offers 2 distinct Mapk14 (MAPK14) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Mapk14 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Mapk14 allele types
Knockout, conditional, knockin, humanized, and related paths for Mapk14 (human MAPK14). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Mapk14 catalog models
2 Mapk14 lines with QC documentation and technical support. Mapk14 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Mapk14 mouse model?
We have 2 Mapk14 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Mapk14 Mouse Model Types
A Mapk14 knockout mouse has the Mapk14 gene permanently inactivated, enabling loss of function studies. A Mapk14 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Mapk14, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Mapk14 organized by modification type. Each URL is indexable and matches common search patterns.