What Mapt Conditional Knockout mouse models are available?

When Mapt Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Mapt knockout embryonic lethal in mice?

It depends on background and allele design. Some Mapt germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Mapt animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Mapt?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●6 Models Available

Mapt Conditional Knockout, Knockin, Knockout mouse models

Browse 6 Mapt mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Mapt conditional knockout mouse, Mapt knockin mouse, Mapt knockout mouse, Mapt xenograft-applicable mouse. Request a quote within 24 hours.

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Why model Mapt

Mapt, the mouse ortholog of human MAPT, encodes tau, a natively unfolded microtubule-associated protein whose carboxy-terminal repeat domain binds along the microtubule lattice to promote assembly and regulate axonal transport, while its projection domain and extensive phosphorylation by GSK3 beta, CDK5, and MARK kinases control detachment and aggregation propensity. A decisive species difference drives model design: adult mouse brain expresses almost exclusively four-repeat tau, whereas human brain expresses balanced three-repeat and four-repeat isoforms generated by exon 10 splicing, so intronic and exonic FTDP-17 mutations that shift isoform ratio cannot be modeled on the mouse locus and require humanized MAPT knockin alleles carrying the full genomic region. Coding mutations such as P301S and P301L instead drive filament formation and are commonly modeled by knockin or transgene. Nulls are viable with mild phenotypes because Map1b and Map2 compensate, so deletion answers requirement while humanized or aggregation-prone knockins answer tauopathy mechanism and antibody or antisense oligonucleotide response.

What Mapt mouse models are available?

ingenious targeting laboratory offers 6 distinct Mapt (MAPT) catalog mouse models, featuring conditional knockout, standard knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
6 Ready Catalog Lines	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Xenograft Applicable Strains

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Xenograft Applicable Strains

Mapt model types

PathAvailability

Knockout
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Conditional knockout
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Knockin
View catalog
Humanized
Request a quote
Transgenic / overexpression
Request a quote

Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Mapt allele types

Knockout, conditional, knockin, humanized, and related paths for Mapt (human MAPT). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO (floxed / loxP)

Inducible conditional KO (CreER / tet)

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first (tm1a / IKMC)

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)

Tag KI (FLAG, HA, Myc, V5)

Conditional KI (e.g. Rosa26 LSL)

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Transgenic

Random integration transgenic

Safe harbor (ROSA26, HPRT, H11, Col1a1)

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre (CreER / tet)

Tamoxifen or dox inducible Cre

Dual recombinase (Cre+Dre / Cre+Flp)

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Reporter knockin (gene specific)

Standalone reporter catalog (lineage tracing, constitutive, dual reporter)

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6 (B6J / B6N)

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Ready to ship

Search 14,774 strains. Many ship from live colonies.

Browse by gene, model type, or therapeutic area. Live colonies available for many top requested knockouts, knockins, and humanized lines.

Trp53Tumor suppressor, knockout & knockin Brca1Breast cancer model, multiple alleles Rosa26Safe harbor for reporters & cassettes

Browse Full Catalog

Model generation

Need a knockout, knockin, or humanized line?

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 100% germline transmission guarantee.

Conventional and conditional knockouts
Point mutation and humanized knockins
2,800+ models generated since 1998

Request a Quote Explore model generation services

Available Mapt catalog models

6 Mapt lines with QC documentation and technical support. Mapt floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

Mapt-Flox
Conditional Knockout
KO/CKO mice
sperm cryopreservationCKO 2118651
Order
Mapt-R5H
Knockin
point mutantion mice
sperm cryopreservationKI 215099
Order
Mapt-KO
Knockout
KO/CKO mice
liveKO 190837
Order
Mapt-hMAPT-P301S/hAPOE4
Xenograft-Applicable
Target humanized mice
liveXA 240812
Order
Mapt-hMAPT-P301S/hAppNL-G-F
Xenograft-Applicable
point mutantion mice, Target humanized mice
liveXA 250110
Order
Mapt-hMAPT-P301S/hTFRC
Xenograft-Applicable
point mutantion mice, Target humanized mice
liveXA 251610
Order

Selected publications from ingenious targeting laboratory

Peer reviewed work involving Mapt (MAPT) from ITL supported projects.

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagationSaito T, Mihira N, Matsuba Y, Sasaguri H, Hashimoto S, Narasimhan S, Zhang B, Murayama S, Higuchi M, Lee VMY, Trojanowski JQ, Saido TC. (2019). J Biol Chem 294(34): 12754-12765

View all ITL publications

Looking for a Mapt mouse model?

We have 6 Mapt models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation

About Mapt Mouse Model Types

A Mapt knockout mouse has the Mapt gene permanently inactivated, enabling loss of function studies. A Mapt conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Mapt, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Mapt knockin models carry a precisely inserted sequence at the Mapt locus, useful for reporter, tag, or humanization studies.

Knockout Mouse Models Conditional Knockout Mouse Models Knockin Mouse Models Mouse Model Generation Services

Modifications available

Jump to catalog backed pages for Mapt organized by modification type. Each URL is indexable and matches common search patterns.

Mapt Conditional Knockout Mapt Knockin Mapt Knockout Mapt Xenograft-Applicable Mapt cDNA Knockin Mapt Epitope Tag Knockin Mapt Humanized Mapt Inducible Knockout Mapt Reporter

Tissue-specific options

Catalog backed tissue and driver restricted routes for Mapt.

neural Mapt conditional knockout

Related Gene Targets

Map1a Map1lc3a Map1lc3b Map2 Map2k1 Map2K2 Map2k3 Map2k3os Map2k5 Map2k6