Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
LIVE · SPERM
Mapt Conditional Knockout, Knockin, Knockout mouse models
Browse 3 Mapt mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Mapt conditional knockout mouse, Mapt knockin mouse, Mapt knockout mouse. Request a quote within 24 hours.
Why model Mapt
Mapt, the mouse ortholog of human MAPT, encodes tau, a natively unfolded microtubule-associated protein whose carboxy-terminal repeat domain binds along the microtubule lattice to promote assembly and regulate axonal transport, while its projection domain and extensive phosphorylation by GSK3 beta, CDK5, and MARK kinases control detachment and aggregation propensity. A decisive species difference drives model design: adult mouse brain expresses almost exclusively four-repeat tau, whereas human brain expresses balanced three-repeat and four-repeat isoforms generated by exon 10 splicing, so intronic and exonic FTDP-17 mutations that shift isoform ratio cannot be modeled on the mouse locus and require humanized MAPT knockin alleles carrying the full genomic region. Coding mutations such as P301S and P301L instead drive filament formation and are commonly modeled by knockin or transgene. Nulls are viable with mild phenotypes because Map1b and Map2 compensate, so deletion answers requirement while humanized or aggregation-prone knockins answer tauopathy mechanism and antibody or antisense oligonucleotide response.
What Mapt mouse models are available?
ingenious targeting laboratory offers 3 distinct Mapt (MAPT) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Mapt model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Mapt allele types
Knockout, conditional, knockin, humanized, and related paths for Mapt (human MAPT). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Mapt catalog models
3 Mapt lines with QC documentation and technical support. Mapt floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Mapt-Flox
CKOCKO
These mice carry loxP sites flanking exon 5-6 of Mapt gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Mapt gene.
Sperm CryopreservedCKO 2118651 - Order
Mapt-R5H
KIPoint Mutation
These mice carry a R5H mutation of Mapt gene.
Sperm CryopreservedKI 215099 - Order
Mapt-KO
KOKO
Exon 4-6 of Mapt gene was deleted to generate Mapt knockout mice.
LiveKO 190837
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Mapt (MAPT) from ingenious supported projects.
- Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagationSaito T, Mihira N, Matsuba Y, Sasaguri H, Hashimoto S, Narasimhan S, Zhang B, Murayama S, Higuchi M, Lee VMY, Trojanowski JQ, Saido TC. (2019). J Biol Chem 294(34): 12754-12765
Looking for a Mapt mouse model?
We have 3 Mapt models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Mapt Mouse Model Types
A Mapt knockout mouse has the Mapt gene permanently inactivated, enabling loss of function studies. A Mapt conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Mapt, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Mapt knockin models carry a precisely inserted sequence at the Mapt locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Mapt organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Mapt.
Breed this line with ingenious targeting laboratory
Send the Mapt line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.