Conventional / global / constitutive KO
●3 Models Available
Mmp13 Conditional Knockout, Knockout mouse models
Browse 3 Mmp13 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Mmp13 conditional knockout mouse, Mmp13 knockout mouse. Contact us for availability and fast turnaround.
Why model Mmp13
Encoding collagenase 3, Mmp13 is the mouse ortholog of human MMP13 and the principal rodent interstitial collagenase, secreted as a zymogen activated by MMP2, MMP14, or plasmin and inhibited by TIMPs, with a catalytic domain that cleaves type I, II, and III collagen and a hemopexin domain that also permits degradation of aggrecan fragments, fibronectin, and perlecan. Transcription is driven by RUNX2, interleukin 1 beta, and MAPK signaling, and the enzyme is the dominant proteolytic driver of osteoarthritic cartilage loss as well as a required participant in growth plate remodeling and endochondral ossification, where compound loss with Mmp9 produces severe skeletal phenotypes. Design should therefore favor conditional deletion, using Col2a1-CreER or Acan-CreER for cartilage and osteoblast drivers for bone, rather than germline nulls that confound development with disease. Catalytically inactive knockins separate proteolysis from other functions, and humanization supports selective inhibitor testing where MMP1 cross-reactivity is the liability.
What Mmp13 mouse models are available?
ingenious targeting laboratory offers 3 distinct Mmp13 (MMP13) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Mmp13 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Mmp13 allele types
Knockout, conditional, knockin, humanized, and related paths for Mmp13 (human MMP13). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Mmp13 catalog models
3 Mmp13 lines with QC documentation and technical support. Mmp13 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Mmp13 mouse model?
We have 3 Mmp13 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Mmp13 Mouse Model Types
A Mmp13 knockout mouse has the Mmp13 gene permanently inactivated, enabling loss of function studies. A Mmp13 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Mmp13, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Mmp13 organized by modification type. Each URL is indexable and matches common search patterns.