Conventional / global / constitutive KO
●2 Models Available
Mmp14 Conditional Knockout, Knockout mouse models
Browse 2 Mmp14 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Mmp14 conditional knockout mouse, Mmp14 knockout mouse. Contact us for availability and fast turnaround.
Why model Mmp14
Mmp14 corresponds to human MMP14 and encodes MT1-MMP, the membrane anchored metalloproteinase that concentrates proteolysis at the cell surface through a transmembrane segment and short cytoplasmic tail directing it into invadopodia and controlling internalization and recycling. It cleaves type I, II, and III collagen directly, sheds CD44 and syndecan, and serves as the physiologic activator of pro-MMP2 using TIMP2 as a bridging cofactor, making it the apex node of pericellular matrix turnover. Germline nulls are severely affected, with dwarfism, craniofacial and skeletal dysplasia, fibrosis, and death by weaning, mirroring human MMP14 lesions that cause multicentric osteolysis nodulosis and arthropathy, so viability alone dictates conditional design. Use floxed alleles with endothelial, fibroblast, chondrocyte, or tumor cell restricted Cre lines to separate developmental from disease contributions, catalytically dead knockins to isolate proteolysis from receptor shedding, and humanization when antibody selectivity against the human catalytic cleft is the endpoint.
What Mmp14 mouse models are available?
ingenious targeting laboratory offers 2 distinct Mmp14 (MMP14) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Mmp14 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Mmp14 allele types
Knockout, conditional, knockin, humanized, and related paths for Mmp14 (human MMP14). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Mmp14 catalog models
2 Mmp14 lines with QC documentation and technical support. Mmp14 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Mmp14 mouse model?
We have 2 Mmp14 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Mmp14 Mouse Model Types
A Mmp14 knockout mouse has the Mmp14 gene permanently inactivated, enabling loss of function studies. A Mmp14 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Mmp14, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Mmp14 organized by modification type. Each URL is indexable and matches common search patterns.