Conventional / global / constitutive KO
●2 Models Available
Msh2 Conditional Knockout mouse models
Browse 2 Msh2 mouse models including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Msh2
Msh2, the mouse ortholog of human MSH2, encodes the common subunit of both mismatch recognition complexes, pairing with Msh6 to form MutSalpha for base-base mispairs and small insertion or deletion loops and with Msh3 to form MutSbeta for larger loops; mismatch binding stimulates its Walker-motif ATPase, converting the heterodimer into a sliding clamp that recruits MutLalpha and licenses strand-specific excision, and the same machinery drives triplet repeat expansion and mediates the cytotoxicity of methylating agents. Germline biallelic loss causes constitutional mismatch repair deficiency and monoallelic loss causes Lynch syndrome, with microsatellite instability and hypermutation that confer immune checkpoint sensitivity. Nulls are viable, lymphoma-prone, and tolerant of temozolomide, so germline alleles are usable, while conditional deletion restricts hypermutation to a lineage of interest. ATPase separation-of-function knockins uncouple repair from damage signaling, and humanization supports variant classification. Msh6 and Msh3 are partners rather than substitutes, so no compensation rescues Msh2 loss.
What Msh2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Msh2 (MSH2) catalog mouse models, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Msh2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Msh2 allele types
Knockout, conditional, knockin, humanized, and related paths for Msh2 (human MSH2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Msh2 catalog models
2 Msh2 lines with QC documentation and technical support. Msh2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Msh2 mouse model?
We have 2 Msh2 models available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Msh2 Mouse Model Types
A Msh2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Msh2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Msh2 organized by modification type. Each URL is indexable and matches common search patterns.