Conventional / global / constitutive KO
●3 Models Available
Nfkb1 Conditional Knockout, Knockout mouse models
Browse 3 Nfkb1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Nfkb1 conditional knockout mouse, Nfkb1 knockout mouse. Contact us for availability and fast turnaround.
Why model Nfkb1
Nfkb1, the mouse ortholog of human NFKB1, encodes p105, which is co-translationally and post-translationally processed to the p50 DNA-binding subunit; the precursor contains a Rel homology domain plus a carboxy-terminal ankyrin repeat region that functions as its own inhibitor, sequestering RelA and c-Rel until stimulus-dependent IKK phosphorylation and betaTrCP-mediated degradation of the ankyrin segment release active dimers. Because p50 lacks a transactivation domain, p50 homodimers act as repressors at kappaB sites, so the gene contributes both activating and silencing functions, and p105 additionally scaffolds Map3k8 to link NF-kB and Erk signaling. Homozygous nulls are viable with defective B cell responses, impaired isotype switching, and heightened infection susceptibility, making germline alleles tractable. A nonprocessable p105 knockin separates precursor inhibitor function from p50 output, conditional alleles restrict loss to a lineage, and humanization supports reagent matching. Rela, Relb, c-Rel, and Nfkb2 overlap at target promoters, so compound genetics is often necessary.
What Nfkb1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Nfkb1 (NFKB1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Nfkb1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Nfkb1 allele types
Knockout, conditional, knockin, humanized, and related paths for Nfkb1 (human NFKB1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Nfkb1 catalog models
3 Nfkb1 lines with QC documentation and technical support. Nfkb1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Nfkb1 mouse model?
We have 3 Nfkb1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Nfkb1 Mouse Model Types
A Nfkb1 knockout mouse has the Nfkb1 gene permanently inactivated, enabling loss of function studies. A Nfkb1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Nfkb1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Nfkb1 organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Nfkb1.