Conventional / global / constitutive KO
●4 Models Available
Pdcd1lg2 Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Pdcd1lg2 mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Pdcd1lg2 conditional knockout mouse, Pdcd1lg2 knockin mouse, Pdcd1lg2 knockout mouse. Contact us for availability and fast turnaround.
Why model Pdcd1lg2
Pdcd1lg2, the mouse ortholog of human PDCD1LG2, encodes PD-L2 (B7-DC), a type I transmembrane protein whose IgV and IgC2 ectodomains engage PD-1 with roughly three-fold higher affinity than PD-L1 while also binding the repulsive guidance molecule RGMB on lung interstitial macrophages. Expression is largely restricted to dendritic cells, macrophages, and germinal center B cells and is driven by IL-4 and STAT6 rather than by the interferon gamma axis that dominates Cd274 induction, so PD-L2 shapes type 2 and tissue-resident tolerance more than interferon-driven adaptive resistance. Allele choice follows directly: conditional nulls isolate the ligand contribution of a defined myeloid or dendritic compartment, whereas ectodomain humanization is required whenever a candidate antibody or PD-1 fusion fails to cross-react with mouse protein. Because Cd274 covers much of the same receptor, single knockouts frequently look silent, so plan Cd274 compound genetics and pair the allele with tumor rejection, exhaustion reversal, or airway inflammation endpoints.
What Pdcd1lg2 mouse models are available?
ingenious targeting laboratory offers 4 distinct Pdcd1lg2 (PD-L2) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pdcd1lg2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pdcd1lg2 allele types
Knockout, conditional, knockin, humanized, and related paths for Pdcd1lg2 (human PDCD1LG2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pdcd1lg2 catalog models
4 Pdcd1lg2 lines with QC documentation and technical support. Pdcd1lg2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Pdcd1lg2-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 220276 - Order
Pdcd1lg2-LSL-2A-DTR-2A-EGFP
Knockinfluorescent mouse, otherToolbox of Mice(Non-Cre, fluorescent)
sperm cryopreservationKI 231495 - Order
Pdcd1lg2-KO(2)
KnockoutKO/CKO mice
sperm cryopreservationKO 232970 - Order
Pdcd1lg2-KO
KnockoutKO/CKO mice
embryo cryopreservationKO 190728
Looking for a Pdcd1lg2 mouse model?
We have 4 Pdcd1lg2 models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pdcd1lg2 Mouse Model Types
A Pdcd1lg2 knockout mouse has the Pdcd1lg2 gene permanently inactivated, enabling loss of function studies. A Pdcd1lg2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pdcd1lg2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Pdcd1lg2 knockin models carry a precisely inserted sequence at the Pdcd1lg2 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Pdcd1lg2 organized by modification type. Each URL is indexable and matches common search patterns.