Conventional / global / constitutive KO
●4 Models Available
READY TO SHIP!
SPERM · EMBRYO
Prkn Conditional Knockout, Knockout mouse models
Browse 4 Prkn mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Prkn conditional knockout mouse, Prkn knockout mouse. Contact us for availability and fast turnaround.
Why model Prkn
Parkin, the product of mouse Prkn and ortholog of human PRKN, is an RBR-class E3 ubiquitin ligase built from a ubiquitin-like domain followed by RING0, RING1, IBR, and RING2 modules that hold the catalytic Cys431 in an autoinhibited conformation. Binding of PINK1-generated phospho-Ser65 ubiquitin plus phosphorylation of the parkin Ubl domain releases autoinhibition, allowing thioester transfer and amplification of ubiquitin chains on outer membrane substrates including MFN1, MFN2, and MIRO, committing damaged mitochondria to mitophagy. Recessive exon deletions and missense alleles cause juvenile parkinsonism without Lewy pathology. Because Prkn nulls are viable and lack nigral cell loss, informative designs include conditional null combined with mitochondrial stress, catalytically dead C431S knockins that separate ligase activity from scaffolding, constitutively active W403A-type alleles, and humanization for activator screening. Match allele class to endpoint using dopaminergic Cre drivers and mitophagy reporters rather than expecting spontaneous degeneration.
What Prkn mouse models are available?
ingenious targeting laboratory offers 4 distinct Prkn (PARK2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Prkn model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Prkn allele types
Knockout, conditional, knockin, humanized, and related paths for Prkn (human PRKN). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Prkn catalog models
4 Prkn lines with QC documentation and technical support. Prkn floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Prkn-Flox
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 3 of Prkn gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Prkn gene.
Sperm CryopreservedCKO 200267 - Order
Prkn-KO
KOKO, Disease Model
Prkn-KO mice (Stock No.KO 190335）carry a knockout allele derived from the targeted deletion of exon 3. While Prkn-KO(2) mice (Stock No.KO 191005）mice carrying the exon 4 deletion.
Sperm CryopreservedKO 190335 - Order
Prkn-KO(2)
KOKO, Disease Model
Prkn-KO(2) mice (Stock No.KO 191005）carry a knockout allele derived from the targeted deletion of exon 4. While Prkn-KO mice (Stock No.KO 190335）mice carrying the exon 3 deletion.
F0 Embryo CryopreservedKO 191005 - Order
Prkn-KO(3)
KOKO, Disease Model
exon 3 of Prkn gene was deleted to generate Prkn knockout mice.
F0 Embryo CryopreservedKO 226112
Looking for a Prkn mouse model?
We have 4 Prkn models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Prkn Mouse Model Types
A Prkn knockout mouse has the Prkn gene permanently inactivated, enabling loss of function studies. A Prkn conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Prkn, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Prkn organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Prkn line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.