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Rb1 Conditional Knockout, Knockin, Xenograft-Applicable mouse models

Browse 4 Rb1 mouse models including conditional knockout, knockin, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Rb1 conditional knockout mouse, Rb1 knockin mouse, Rb1 xenograft-applicable mouse. Request a quote within 24 hours.

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Why model Rb1

The prototypic tumor suppressor Rb1, ortholog of human RB1, encodes a pocket protein whose A and B domains form a cleft that binds the transactivation domain of E2F1 through E2F3 and, through a separate LXCXE-binding groove, recruits histone deacetylases and chromatin modifiers as well as viral oncoproteins including E7 and large T antigen. Sequential phosphorylation by cyclin D with CDK4 or CDK6 and then cyclin E with CDK2 releases E2F and licenses S phase entry, the axis targeted by palbociclib, and biallelic loss causes retinoblastoma and is pervasive in small cell lung cancer. Germline deletion is embryonic lethal from placental and erythroid defects, so conditional nulls are standard, and phosphorylation site or LXCXE-cleft knockins separate CDK regulation from chromatin recruitment. Critically, the paralogs Rbl1 and Rbl2 compensate robustly in mouse retina and elsewhere, so compound conditional genetics is usually required to reproduce the human tumor spectrum.

What Rb1 mouse models are available?

ingenious targeting laboratory offers 4 distinct Rb1 (RB1) catalog mouse models, featuring conditional knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model AvailabilityAllele Class Options
4 Ready Catalog LinesConditional Knockout (cKO)
Custom Model GenerationConstitutive Knockout (KO) on request
Advanced ModificationsHumanized, Knockin, Transgenic
Quality Control
Documented Germline Transmission
Quality Control
Strict United States QC Guidelines
Quality Control
Xenograft Applicable Strains

Rb1 model types

Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Rb1 allele types

Knockout, conditional, knockin, humanized, and related paths for Rb1 (human RB1). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Tissue specific KO

Specify tissue or Cre driver on quote

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Double / compound KO

Multi allele / compound knockout project

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Knockin

Humanized

Partial / domain humanized

Domain or partial humanization scope

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Double / multi humanized

Multi humanized / combination IO project

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Targeted Transgenic

Cre / recombinase

Reporter

Species / background

Available Rb1 catalog models

4 Rb1 lines with QC documentation and technical support. Rb1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

  • Rb1-Flox

    CKO

    CKO, Disease Model

    These mice carry loxP sites flanking exon3 of Rb1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Rb1 gene.

    LiveCKO 18012
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  • Rb1-Flox/Trp53-Flox

    CKO

    CKO

    The Rb1-Flox(CKO 18012) was crossed with Trp53-Flox(CKO 18005) to generate Rb1-Flox/Trp53-Flox mice.

    LiveCKO 232461
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  • Rb1-Flox/Trp53-Flox/R26-CAG-LSL-Luc-2A-EGFP

    KI

    CKO, Overexpression, Fluorescent Model

    The Rb1-Flox/Trp53-Flox(CKO 232461) was crossed with R26-CAG-LSL-Luc-2A-EGFP(KI 190095) to generate Rb1-Flox/Trp53-Flox/R26-CAG-LSL-Luc-2A-EGFP mice.

    Embryo CryopreservedKI 234513
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  • Rb1-Flox/Trp53-Flox/Pten-Flox

    XA

    CKO

    The Rb1-Flox/Trp53-Flox(CKO 232461) was crossed with Pten-Flox(CKO 18004) to generate Rb1-Flox/Trp53-Flox/Pten-Flox mice.

    LiveXA 240019
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Looking for a Rb1 mouse model?

We have 4 Rb1 models in stock — including Conditional Knockout, Knockin, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

Order catalog model
4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation

About Rb1 Mouse Model Types

A Rb1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Rb1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Rb1 knockin models carry a precisely inserted sequence at the Rb1 locus, useful for reporter, tag, or humanization studies.

Conditional Knockout Mouse ModelsKnockin Mouse ModelsMouse Model Generation Services

Modifications available

Jump to catalog backed pages for Rb1 organized by modification type. Each URL is indexable and matches common search patterns.

Rb1 Conditional KnockoutRb1 KnockinRb1 Xenograft-ApplicableRb1 cDNA KnockinRb1 Epitope Tag KnockinRb1 HumanizedRb1 Inducible KnockoutRb1 KnockoutRb1 Overexpression / Safe HarborRb1 Reporter

Tissue-specific options

Catalog backed tissue and driver restricted routes for Rb1.

retina Rb1 conditional knockout

Related Gene Targets

Rb1cc1

Breed this line with ingenious targeting laboratory

Send the Rb1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.