Conventional / global / constitutive KO
●4 Models Available
Rb1 Conditional Knockout, Knockin, Xenograft-Applicable mouse models
Browse 4 Rb1 mouse models including conditional knockout, knockin, xenograft-applicable variants — in stock and ready to ship from ingenious targeting laboratory. Available as Rb1 conditional knockout mouse, Rb1 knockin mouse, Rb1 xenograft-applicable mouse. Request a quote within 24 hours.
Why model Rb1
The prototypic tumor suppressor Rb1, ortholog of human RB1, encodes a pocket protein whose A and B domains form a cleft that binds the transactivation domain of E2F1 through E2F3 and, through a separate LXCXE-binding groove, recruits histone deacetylases and chromatin modifiers as well as viral oncoproteins including E7 and large T antigen. Sequential phosphorylation by cyclin D with CDK4 or CDK6 and then cyclin E with CDK2 releases E2F and licenses S phase entry, the axis targeted by palbociclib, and biallelic loss causes retinoblastoma and is pervasive in small cell lung cancer. Germline deletion is embryonic lethal from placental and erythroid defects, so conditional nulls are standard, and phosphorylation site or LXCXE-cleft knockins separate CDK regulation from chromatin recruitment. Critically, the paralogs Rbl1 and Rbl2 compensate robustly in mouse retina and elsewhere, so compound conditional genetics is usually required to reproduce the human tumor spectrum.
What Rb1 mouse models are available?
ingenious targeting laboratory offers 4 distinct Rb1 (RB1) catalog mouse models, featuring conditional knockout, xenograft applicable lines, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Xenograft Applicable Strains
Rb1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Rb1 allele types
Knockout, conditional, knockin, humanized, and related paths for Rb1 (human RB1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Rb1 catalog models
4 Rb1 lines with QC documentation and technical support. Rb1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Rb1-Flox/Trp53-Flox
Conditional KnockoutKO/CKO mice
liveCKO 232461 - Order
Rb1-Flox
Conditional KnockoutKO/CKO mice, disease model mice
liveCKO 18012 - Order
Rb1-Flox/Trp53-Flox/R26-CAG-LSL-Luc-2A-EGFP
KnockinKO/CKO mice, over expression mice, fluorescent mouse
embryo cryopreservationKI 234513 - Order
Rb1-Flox/Trp53-Flox/Pten-Flox
Xenograft-ApplicableKO/CKO mice
embryo cryopreservationXA 240019
Looking for a Rb1 mouse model?
We have 4 Rb1 models in stock — including Conditional Knockout, Knockin, Xenograft-Applicable types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Rb1 Mouse Model Types
A Rb1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Rb1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Rb1 knockin models carry a precisely inserted sequence at the Rb1 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Rb1 organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Rb1.