Conventional / global / constitutive KO
●2 Models Available
Rps6kb1 Conditional Knockout, Knockout mouse models
Browse 2 Rps6kb1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Rps6kb1 conditional knockout mouse, Rps6kb1 knockout mouse. Request a quote within 24 hours.
Why model Rps6kb1
S6 kinase 1, encoded by Rps6kb1 and orthologous to human RPS6KB1, is an AGC kinase recruited to mTORC1 through a TOS motif that binds RAPTOR, then activated by mTOR phosphorylation of the Thr389 hydrophobic motif followed by PDPK1 phosphorylation of Thr229 in the activation loop. Its substrates include ribosomal protein S6, eIF4B, PDCD4, eEF2 kinase and IRS-1, the last constituting the negative feedback loop that limits PI3K signaling and underlies paradoxical insulin sensitization by rapamycin. Nulls are viable but small with hypoinsulinemia and reduced beta cell size, so conditional alleles matter mainly for tissue-autonomous growth questions, while a Thr389 phospho-dead knockin isolates mTORC1 input from PDPK1 input in a way inhibitors cannot. Because Rps6kb2 phosphorylates overlapping substrates and is upregulated after Rps6kb1 loss, compound alleles or an Rps6 phospho-dead knockin should be planned when translation output is the endpoint.
What Rps6kb1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Rps6kb1 (RPS6KB1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Rps6kb1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
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Rps6kb1 allele types
Knockout, conditional, knockin, humanized, and related paths for Rps6kb1 (human RPS6KB1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Rps6kb1 catalog models
2 Rps6kb1 lines with QC documentation and technical support. Rps6kb1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Rps6kb1 mouse model?
We have 2 Rps6kb1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Rps6kb1 Mouse Model Types
A Rps6kb1 knockout mouse has the Rps6kb1 gene permanently inactivated, enabling loss of function studies. A Rps6kb1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Rps6kb1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Rps6kb1 organized by modification type. Each URL is indexable and matches common search patterns.