Conventional / global / constitutive KO
●3 Models Available
Stat3 Conditional Knockout, Knockout mouse models
Browse 3 Stat3 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Stat3 conditional knockout mouse, Stat3 knockout mouse. Request a quote within 24 hours.
Why model Stat3
Signaling from gp130-family cytokines, notably IL-6, IL-11, IL-10 and LIF, converges on Stat3, the ortholog of human STAT3, whose SH2 domain docks phosphorylated receptor tyrosines, is phosphorylated at Tyr705 by JAK1, dimerizes, and drives Socs3, Bcl3 and Myc transcription, with Ser727 phosphorylation and a separate mitochondrial pool supporting electron transport chain activity independently of transcription. Dominant-negative DNA-binding and SH2 domain mutations cause autosomal dominant hyper-IgE syndrome, whereas somatic activating mutations occur in large granular lymphocytic leukemia and germline gain-of-function alleles cause early-onset multiorgan autoimmunity, so patient-matched knockins interrogate mechanisms opposite in sign. Germline deletion is early embryonic lethal, making conditional nulls mandatory for essentially all adult work, and Ser727 phospho-dead knockins isolate the mitochondrial function. Match allele to endpoint: conditional null for tissue requirement, activating knockin for lymphoproliferation and JAK inhibitor response.
What Stat3 mouse models are available?
ingenious targeting laboratory offers 3 distinct Stat3 (STAT3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Stat3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Stat3 allele types
Knockout, conditional, knockin, humanized, and related paths for Stat3 (human STAT3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Stat3 catalog models
3 Stat3 lines with QC documentation and technical support. Stat3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Stat3 mouse model?
We have 3 Stat3 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Stat3 Mouse Model Types
A Stat3 knockout mouse has the Stat3 gene permanently inactivated, enabling loss of function studies. A Stat3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Stat3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Stat3 organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Stat3.