Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
SPERM
Stat3 Conditional Knockout, Knockout mouse models
Browse 3 Stat3 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Stat3 conditional knockout mouse, Stat3 knockout mouse. Contact us for availability and fast turnaround.
Why model Stat3
Signaling from gp130-family cytokines, notably IL-6, IL-11, IL-10 and LIF, converges on Stat3, the ortholog of human STAT3, whose SH2 domain docks phosphorylated receptor tyrosines, is phosphorylated at Tyr705 by JAK1, dimerizes, and drives Socs3, Bcl3 and Myc transcription, with Ser727 phosphorylation and a separate mitochondrial pool supporting electron transport chain activity independently of transcription. Dominant-negative DNA-binding and SH2 domain mutations cause autosomal dominant hyper-IgE syndrome, whereas somatic activating mutations occur in large granular lymphocytic leukemia and germline gain-of-function alleles cause early-onset multiorgan autoimmunity, so patient-matched knockins interrogate mechanisms opposite in sign. Germline deletion is early embryonic lethal, making conditional nulls mandatory for essentially all adult work, and Ser727 phospho-dead knockins isolate the mitochondrial function. Match allele to endpoint: conditional null for tissue requirement, activating knockin for lymphoproliferation and JAK inhibitor response.
What Stat3 mouse models are available?
ingenious targeting laboratory offers 3 distinct Stat3 (STAT3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Stat3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Stat3 allele types
Knockout, conditional, knockin, humanized, and related paths for Stat3 (human STAT3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Stat3 catalog models
3 Stat3 lines with QC documentation and technical support. Stat3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Stat3-Flox(非移码)
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 18-20 of Stat3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Stat3 gene. The experimental strategy was designed with reference to the following publications: (PMID: 14566054; 17660847; 12571365). While Stat3-Flox(Stock No.CKO 200050）mice carrying the loxP sites flanking exon 12-14 of Stat3 gene.
Sperm CryopreservedCKO 200225 - Order
Stat3-Flox
CKOCKO, Disease Model
These mice carry loxP sites flanking exon 12-14 of Stat3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Stat3 gene.While Stat3-Flox(in-frame mutation)(Stock No.CKO 200225）mice carrying the loxP sites flanking exon 18-20 of Stat3 gene.
Sperm CryopreservedCKO 200050 - Order
Stat3-KO(非移码)
KOKO
exon 18-20 of Stat3 gene was deleted to generate Stat3 knockout mice. The targeted knockout region mirrors that of the CKO 200225 strain, with the experimental strategy designed according to published methodologies (PMID: 14566054; 17660847; 12571365).Lethality associated with this genetic modification has been documented. For details, click on the MGI ID in the genetic information.
Sperm CryopreservedKO 210186
Looking for a Stat3 mouse model?
We have 3 Stat3 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Stat3 Mouse Model Types
A Stat3 knockout mouse has the Stat3 gene permanently inactivated, enabling loss of function studies. A Stat3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Stat3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Stat3 organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Stat3.
Breed this line with ingenious targeting laboratory
Send the Stat3 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.